Cited 6 times in
Laboratory Aspects of Donor Screening for Fecal Microbiota Transplantation at a Korean Fecal Microbiota Bank
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.date.accessioned | 2021-09-29T00:37:23Z | - |
dc.date.available | 2021-09-29T00:37:23Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183960 | - |
dc.description.abstract | Fecal microbiota transplantation (FMT) is a widely accepted alternative therapy for Clostridioides difficile infection and other gastrointestinal disorders. Thorough donor screening is required as a safety control measure to minimize transmission of infectious agents in FMT. We report the donor screening process and outcomes at a fecal microbiota bank in Korea. From August 2017 to June 2020, the qualification of 62 individuals as FMT donors was evaluated using clinical assessment and laboratory tests. Forty-six (74%) candidates were excluded after clinical assessment; high body mass index (>25) was the most common reason for exclusion, followed by atopy, asthma, and allergy history. Four of the remaining 16 (25%) candidates failed to meet laboratory test criteria, resulting in a 19% qualification rate. FMT donor re-qualification was conducted monthly as an additional safety control measure, and only three (5%) candidates were eligible for repeated donation. As high prevalence of multidrug-resistant organisms (55%) and Helicobacter pylori (44%) were detected in qualified donors during the screening, a urea breath test was added to the existing protocol. The present results emphasize the importance of implementing a donor re-qualification system to minimize risk factors not identified during initial donor screening. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society for Laboratory Medicine | - |
dc.relation.isPartOf | ANNALS OF LABORATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Laboratory Aspects of Donor Screening for Fecal Microbiota Transplantation at a Korean Fecal Microbiota Bank | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Hyun Soo Seo | - |
dc.contributor.googleauthor | Hyung Sun Chin | - |
dc.contributor.googleauthor | Yeon-Hee Kim | - |
dc.contributor.googleauthor | Hye Su Moon | - |
dc.contributor.googleauthor | Kyungnam Kim | - |
dc.contributor.googleauthor | Le Phuong Nguyen | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.identifier.doi | 10.3343/alm.2021.41.4.424 | - |
dc.contributor.localId | A02423 | - |
dc.relation.journalcode | J00164 | - |
dc.identifier.eissn | 2234-3814 | - |
dc.identifier.pmid | 33536363 | - |
dc.subject.keyword | Donor screening | - |
dc.subject.keyword | Fecal microbiota bank | - |
dc.subject.keyword | Fecal microbiota transplantation | - |
dc.subject.keyword | Korea | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | 용동은 | - |
dc.citation.volume | 41 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 424 | - |
dc.citation.endPage | 428 | - |
dc.identifier.bibliographicCitation | ANNALS OF LABORATORY MEDICINE, Vol.41(4) : 424-428, 2021-07 | - |
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