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Laboratory Aspects of Donor Screening for Fecal Microbiota Transplantation at a Korean Fecal Microbiota Bank

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dc.contributor.author용동은-
dc.date.accessioned2021-09-29T00:37:23Z-
dc.date.available2021-09-29T00:37:23Z-
dc.date.issued2021-07-
dc.identifier.issn2234-3806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/183960-
dc.description.abstractFecal microbiota transplantation (FMT) is a widely accepted alternative therapy for Clostridioides difficile infection and other gastrointestinal disorders. Thorough donor screening is required as a safety control measure to minimize transmission of infectious agents in FMT. We report the donor screening process and outcomes at a fecal microbiota bank in Korea. From August 2017 to June 2020, the qualification of 62 individuals as FMT donors was evaluated using clinical assessment and laboratory tests. Forty-six (74%) candidates were excluded after clinical assessment; high body mass index (>25) was the most common reason for exclusion, followed by atopy, asthma, and allergy history. Four of the remaining 16 (25%) candidates failed to meet laboratory test criteria, resulting in a 19% qualification rate. FMT donor re-qualification was conducted monthly as an additional safety control measure, and only three (5%) candidates were eligible for repeated donation. As high prevalence of multidrug-resistant organisms (55%) and Helicobacter pylori (44%) were detected in qualified donors during the screening, a urea breath test was added to the existing protocol. The present results emphasize the importance of implementing a donor re-qualification system to minimize risk factors not identified during initial donor screening.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Laboratory Medicine-
dc.relation.isPartOfANNALS OF LABORATORY MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleLaboratory Aspects of Donor Screening for Fecal Microbiota Transplantation at a Korean Fecal Microbiota Bank-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.googleauthorHyun Soo Seo-
dc.contributor.googleauthorHyung Sun Chin-
dc.contributor.googleauthorYeon-Hee Kim-
dc.contributor.googleauthorHye Su Moon-
dc.contributor.googleauthorKyungnam Kim-
dc.contributor.googleauthorLe Phuong Nguyen-
dc.contributor.googleauthorDongeun Yong-
dc.identifier.doi10.3343/alm.2021.41.4.424-
dc.contributor.localIdA02423-
dc.relation.journalcodeJ00164-
dc.identifier.eissn2234-3814-
dc.identifier.pmid33536363-
dc.subject.keywordDonor screening-
dc.subject.keywordFecal microbiota bank-
dc.subject.keywordFecal microbiota transplantation-
dc.subject.keywordKorea-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.affiliatedAuthor용동은-
dc.citation.volume41-
dc.citation.number4-
dc.citation.startPage424-
dc.citation.endPage428-
dc.identifier.bibliographicCitationANNALS OF LABORATORY MEDICINE, Vol.41(4) : 424-428, 2021-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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