Cited 10 times in
Risk Factors for Postoperative Recurrence in Korean Patients with Crohn's Disease
DC Field | Value | Language |
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dc.contributor.author | 박재준 | - |
dc.contributor.author | 천재희 | - |
dc.date.accessioned | 2021-09-29T00:36:42Z | - |
dc.date.available | 2021-09-29T00:36:42Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183953 | - |
dc.description.abstract | Background/aims: A considerable number of patients with Crohn's disease still need intestinal resection surgery. Postoperative recurrence is an important issue in Crohn's disease management, including the selection of high-risk patients. Eastern Asian patients showed several differences from Caucasian patients. Therefore, we investigated the postoperative surgical recurrence outcome and identified risk factors in Korean patients. Methods: Clinical data of 372 patients with Crohn's disease who underwent first intestinal resection between January 2004 and August 2014 at 14 hospitals in Korea were retrospectively reviewed. Results: Over the follow-up period, 50 patients (17.1%) showed surgical recurrence. The cumulative surgical recurrence rate was 6.5% at 1 year and 15.4% at 7 years. Age under 16 (p=0.011; hazard ratio [HR], 5.136; 95% confidence interval [CI], 1.576 to 16.731), colonic involvement (p=0.023; HR , 2.011; 95% CI, 1.102 to 3.670), and the presence of perianal disease at surgery (p=0.008; HR, 2.239; 95% CI, 1.236 to 4.059) were independent risk factors associated with surgical recurrence. Postoperative thiopurine treatment (p=0.002; HR, 0.393; 95% CI, 0.218 to 0.710) was a protective factor for surgical recurrence. Conclusions: Among the disease characteristics at surgery, younger age, colonic location, and perianal lesions were independent risk factors for surgical recurrence. Postoperative thiopurine treatment significantly reduced the incidence of surgical recurrence. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Editorial Office of Gut and Liver | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Crohn Disease / epidemiology | - |
dc.subject.MESH | Crohn Disease / pathology* | - |
dc.subject.MESH | Crohn Disease / surgery* | - |
dc.subject.MESH | Endoscopy, Gastrointestinal / statistics & numerical data* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Postoperative Complications / epidemiology* | - |
dc.subject.MESH | Postoperative Complications / etiology* | - |
dc.subject.MESH | Postoperative Period | - |
dc.subject.MESH | Recurrence | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Risk Factors for Postoperative Recurrence in Korean Patients with Crohn's Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sung Bae Kim | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.contributor.googleauthor | Jae Jun Park | - |
dc.contributor.googleauthor | Eun Soo Kim | - |
dc.contributor.googleauthor | Seong Woo Jeon | - |
dc.contributor.googleauthor | Sung-Ae Jung | - |
dc.contributor.googleauthor | Dong Il Park | - |
dc.contributor.googleauthor | Chang Kyun Lee | - |
dc.contributor.googleauthor | Jong Pil Im | - |
dc.contributor.googleauthor | You Sun Kim | - |
dc.contributor.googleauthor | Hyun Soo Kim | - |
dc.contributor.googleauthor | Jun Lee | - |
dc.contributor.googleauthor | Chang Soo Eun | - |
dc.contributor.googleauthor | Jeong Mi Lee | - |
dc.contributor.googleauthor | Byung Ik Jang | - |
dc.contributor.googleauthor | Geom Seog Seo | - |
dc.identifier.doi | 10.5009/gnl19085 | - |
dc.contributor.localId | A01636 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J00954 | - |
dc.identifier.eissn | 2005-1212 | - |
dc.identifier.pmid | 31550869 | - |
dc.subject.keyword | Crohn disease | - |
dc.subject.keyword | Recurrence | - |
dc.subject.keyword | Risk factors | - |
dc.subject.keyword | Surgery | - |
dc.subject.keyword | Thiopurine | - |
dc.contributor.alternativeName | Park, Jae Jun | - |
dc.contributor.affiliatedAuthor | 박재준 | - |
dc.contributor.affiliatedAuthor | 천재희 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 331 | - |
dc.citation.endPage | 337 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, Vol.14(3) : 331-337, 2020-05 | - |
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