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Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells
DC Field | Value | Language |
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dc.contributor.author | 주동진 | - |
dc.date.accessioned | 2021-09-29T00:36:25Z | - |
dc.date.available | 2021-09-29T00:36:25Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183949 | - |
dc.description.abstract | Invariant natural killer T (iNKT), mucosal-associated invariant T (MAIT), and γδ T cells are innate T cells that acquire memory phenotype in the thymus and share similar biological characteristics. However, how their effector differentiation is developmentally regulated is still unclear. Here, we identify analogous effector subsets of these three innate T cell types in the thymus that share transcriptional profiles. Using single-cell RNA sequencing, we show that iNKT, MAIT and γδ T cells mature via shared, branched differentiation rather than linear maturation or TCR-mediated instruction. Simultaneous TCR clonotyping analysis reveals that thymic maturation of all three types is accompanied by clonal selection and expansion. Analyses of mice deficient of TBET, GATA3 or RORγt and additional in vivo experiments corroborate the predicted differentiation paths, while human innate T cells from liver samples display similar features. Collectively, our data indicate that innate T cells share effector differentiation processes in the thymus. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Pub. Group | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Differentiation* | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Clonal Selection, Antigen-Mediated | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunity, Innate* | - |
dc.subject.MESH | Liver / cytology | - |
dc.subject.MESH | Liver / immunology | - |
dc.subject.MESH | Lymphocyte Activation | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mucosal-Associated Invariant T Cells / metabolism | - |
dc.subject.MESH | Natural Killer T-Cells / metabolism | - |
dc.subject.MESH | Sequence Analysis, RNA | - |
dc.subject.MESH | Single-Cell Analysis | - |
dc.subject.MESH | T-Lymphocytes / metabolism* | - |
dc.subject.MESH | Th17 Cells / metabolism | - |
dc.subject.MESH | Thymus Gland / cytology | - |
dc.subject.MESH | Thymus Gland / immunology* | - |
dc.title | Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Minji Lee | - |
dc.contributor.googleauthor | Eunmin Lee | - |
dc.contributor.googleauthor | Seong Kyu Han | - |
dc.contributor.googleauthor | Yoon Ha Choi | - |
dc.contributor.googleauthor | Dong-Il Kwon | - |
dc.contributor.googleauthor | Hyobeen Choi | - |
dc.contributor.googleauthor | Kwanghwan Lee | - |
dc.contributor.googleauthor | Eun Seo Park | - |
dc.contributor.googleauthor | Min-Seok Rha | - |
dc.contributor.googleauthor | Dong Jin Joo | - |
dc.contributor.googleauthor | Eui-Cheol Shin | - |
dc.contributor.googleauthor | Sanguk Kim | - |
dc.contributor.googleauthor | Jong Kyoung Kim | - |
dc.contributor.googleauthor | You Jeong Lee | - |
dc.identifier.doi | 10.1038/s41467-020-18155-8 | - |
dc.contributor.localId | A03948 | - |
dc.relation.journalcode | J02293 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.pmid | 32868763 | - |
dc.contributor.alternativeName | Joo, Dong Jin | - |
dc.contributor.affiliatedAuthor | 주동진 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 4367 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, Vol.11(1) : 4367, 2020-08 | - |
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