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Impact of extended-criteria donor lungs according to preoperative recipient status and age in lung transplantation
DC Field | Value | Language |
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dc.contributor.author | 김송이 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 백효채 | - |
dc.contributor.author | 서지원 | - |
dc.contributor.author | 이진구 | - |
dc.contributor.author | 정수진 | - |
dc.date.accessioned | 2021-09-29T00:33:48Z | - |
dc.date.available | 2021-09-29T00:33:48Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1298-1711 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183915 | - |
dc.description.abstract | Background: Organ donor shortage remains as one of the limiting factors for lung transplantation. Given the increase in waiting time, preoperative condition has worsened and affects surgical outcomes. This study aimed to evaluate the immediate postoperative and long-term outcomes of lung transplantation in extended-criteria donor (ECD) lungs compared with standard-criteria donor (SCD) lungs. Methods: A total of 246 patients who had undergone double-lung transplantation during the study period were enrolled. SCD was defined based on the following characteristics: age <55 years, <20 pack-years smoking history, and PaO2/fraction of O2 ratio >300 mmHg. Organ donors who do not fulfill these criteria were classified as ECD. Pre- and postoperative data for outcomes and survival data were analyzed. Results: ECD showed significant association with extracorporeal membrane oxygenation weaning in the operating room (hazard ratio [HR], 0.531; 95% confidence interval [CI], 0.291–0.970; P=0.039) considering recipient’s age and status at operation. The ECD group showed comparable survival rate with the SCD group (HR, 1.413; 95% CI, 0.885– 2.255; P=0.148), with adjustment of other factors. However, when the recipient had Korean Network for Organ Sharing (KONOS) status 0 at the time of transplantation (HR, 1.662; 95% CI, 1.025–2.568; P=0.039), G3 primary graft dysfunction at 72 hours after surgery (HR, 2.508; 95% CI, 1.416–4.440; P=0.002) was a risk factor that decreased survival. Conclusions: The outcome of ECD is not inferior to that of SCD. Therefore, ECD lung should be considered a potential donor organ following active donor management rather than a contraindication of transplantation in highly selected recipients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Journal of the Korean Society for Transplantation | - |
dc.publisher | Journal of the Korean Society for Transplantation | - |
dc.relation.isPartOf | Journal of the Korean Society for Transplantation | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Impact of extended-criteria donor lungs according to preoperative recipient status and age in lung transplantation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jee Won Suh | - |
dc.contributor.googleauthor | Jin Gu Lee | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.contributor.googleauthor | Song Yee Kim | - |
dc.contributor.googleauthor | Su Jin Jeong | - |
dc.contributor.googleauthor | Hyo Chae Paik | - |
dc.identifier.doi | 10.4285/kjt.2020.34.3.185 | - |
dc.contributor.localId | A00626 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A01846 | - |
dc.contributor.localId | A04956 | - |
dc.contributor.localId | A03225 | - |
dc.contributor.localId | A03638 | - |
dc.relation.journalcode | J01858 | - |
dc.identifier.eissn | 2508-2604 | - |
dc.subject.keyword | Lung transplantation | - |
dc.subject.keyword | Donor | - |
dc.subject.keyword | Extended criteria donor | - |
dc.contributor.alternativeName | Kim, Song Yee | - |
dc.contributor.affiliatedAuthor | 김송이 | - |
dc.contributor.affiliatedAuthor | 박무석 | - |
dc.contributor.affiliatedAuthor | 백효채 | - |
dc.contributor.affiliatedAuthor | 서지원 | - |
dc.contributor.affiliatedAuthor | 이진구 | - |
dc.contributor.affiliatedAuthor | 정수진 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 185 | - |
dc.citation.endPage | 192 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society for Transplantation, Vol.34(3) : 185-192, 2020-09 | - |
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