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Locally Controlled Diffusive Release of Bone Morphogenetic Protein-2 Using Micropatterned Gelatin Methacrylate Hydrogel Carriers
DC Field | Value | Language |
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dc.contributor.author | 이근우 | - |
dc.date.accessioned | 2021-09-29T00:33:13Z | - |
dc.date.available | 2021-09-29T00:33:13Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 1976-0280 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183910 | - |
dc.description.abstract | In this work, a novel and simple bone morphogenetic protein (BMP)-2 carrier is developed, which enables localized and controlled release of BMP-2 and facilitates bone regeneration. BMP-2 is localized in the gelatin methacrylate (GelMA) micropatterns on hydrophilic semi-permeable membrane (SNM), and its controlled release is regulated by the concentration of GelMA hydrogel and BMP-2. The controlled release of BMP-2 is verified using computational analysis and quantified using fluorescein isothiocyanate-bovine serum albumin (FITC-BSA) diffusion model. The osteogenic differentiation of osteosarcoma MG-63 cells is manipulated by localized and controlled BMP-2 release. The calcium deposits are significantly higher and the actin skeletal networks are denser in MG-63 cells cultured in the BMP-2-immobilized GelMA micropattern than in the absence of BMP-2. The proposed BMP-2 carrier is expected to not only act as a barrier membrane that can prevent invasion of connective tissue during bone regeneration, but also as a carrier capable of localizing and controlling the release of BMP-2 due to GelMA micropatterning on SNM. This approach can be extensively applied to tissue engineering, including the localization and encapsulation of cells or drugs. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Biochip Society | - |
dc.relation.isPartOf | BIOCHIP JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Locally Controlled Diffusive Release of Bone Morphogenetic Protein-2 Using Micropatterned Gelatin Methacrylate Hydrogel Carriers | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Prosthodontics (보철과학교실) | - |
dc.contributor.googleauthor | Myong-Hee Yi | - |
dc.contributor.googleauthor | Ji-Eun Lee | - |
dc.contributor.googleauthor | Chang-Beom Kim | - |
dc.contributor.googleauthor | Keun-Woo Lee | - |
dc.contributor.googleauthor | Kwang-Ho Lee | - |
dc.identifier.doi | 10.1007/s13206-020-4411-0 | - |
dc.contributor.localId | A02688 | - |
dc.relation.journalcode | J00292 | - |
dc.identifier.eissn | 2092-7843 | - |
dc.identifier.pmid | 33250969 | - |
dc.subject.keyword | Bone generation | - |
dc.subject.keyword | Bone morphogenetic protein-2 | - |
dc.subject.keyword | Controlled release | - |
dc.subject.keyword | Gelatin-methacrylate | - |
dc.subject.keyword | Localized release | - |
dc.contributor.alternativeName | Lee, Keun Woo | - |
dc.contributor.affiliatedAuthor | 이근우 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 405 | - |
dc.citation.endPage | 420 | - |
dc.identifier.bibliographicCitation | BIOCHIP JOURNAL, Vol.14(4) : 405-420, 2020-12 | - |
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