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Sirtuin 1 and endothelial glycocalyx
DC Field | Value | Language |
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dc.contributor.author | 송종욱 | - |
dc.date.accessioned | 2021-09-29T00:30:12Z | - |
dc.date.available | 2021-09-29T00:30:12Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 0031-6768 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183876 | - |
dc.description.abstract | Sirtuin1 deficiency or reduced activity comprises one of the hallmarks of diseases as diverse as chronic cardiovascular, renal, and metabolic, some malignancies, and infections, as well as aging-associated diseases. In a mouse model of endothelium-limited defect in sirtuin 1 deacetylase activity, we found a dramatic reduction in the volume of endothelial glycocalyx. This was associated with the surge in the levels of one of key scaffolding heparan sulfate proteoglycans of endothelial glycocalyx, syndecan-4, and specifically, its extracellular domain (ectodomain). We found that the defect in endothelial sirtuin 1 deacetylase activity is associated with (a) elevated basal and stimulated levels of superoxide generation (via the FoxO1 over-acetylation mechanism) and (b) increased nuclear translocation of NF-kB (via p65 over-acetylation mechanism). These findings laid the foundation for the proposed novel function of sirtuin 1, namely, the maintenance of endothelial glycocalyx, particularly manifest in conditions associated with sirtuin 1 depletion. In the forthcoming review, we summarize the emerging conceptual framework of the enhanced glycocalyx degradation in the states of defective endothelial sirtuin 1 function, thus explaining a broad footprint of the syndrome of endothelial dysfunction, from impaired flow-induced nitric oxide production, deterrent leukocytes infiltration, increased endothelial permeability, coagulation, and pro-inflammatory changes to development of microvascular rarefaction and progression of an underlying disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | German, English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Endothelial Cells / metabolism* | - |
dc.subject.MESH | Endothelium / metabolism* | - |
dc.subject.MESH | Glycocalyx / metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Nitric Oxide / metabolism | - |
dc.subject.MESH | Sirtuin 1 / metabolism* | - |
dc.title | Sirtuin 1 and endothelial glycocalyx | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Mark Lipphardt | - |
dc.contributor.googleauthor | Jong Wook Song | - |
dc.contributor.googleauthor | Michael S Goligorsky | - |
dc.identifier.doi | 10.1007/s00424-020-02407-z | - |
dc.contributor.localId | A02060 | - |
dc.relation.journalcode | J02502 | - |
dc.identifier.eissn | 1432-2013 | - |
dc.identifier.pmid | 32494847 | - |
dc.subject.keyword | Glycocalyx | - |
dc.subject.keyword | NF-kB | - |
dc.subject.keyword | Oxidative stress | - |
dc.subject.keyword | Sheddases | - |
dc.subject.keyword | Sirtuin 1 | - |
dc.subject.keyword | Syndecan-4 | - |
dc.contributor.alternativeName | Song, Jong Wook | - |
dc.contributor.affiliatedAuthor | 송종욱 | - |
dc.citation.volume | 472 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 991 | - |
dc.citation.endPage | 1002 | - |
dc.identifier.bibliographicCitation | PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Vol.472(8) : 991-1002, 2020-08 | - |
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