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Elevated testosterone increases risk of hepatocellular carcinoma in men with chronic hepatitis B and diabetes mellitus
DC Field | Value | Language |
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dc.contributor.author | 이혜원 | - |
dc.date.accessioned | 2021-09-29T00:28:40Z | - |
dc.date.available | 2021-09-29T00:28:40Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183854 | - |
dc.description.abstract | Background and aim: Male sex is a risk factor for hepatocellular carcinoma (HCC). Diabetes mellitus (DM) is associated with a doubled risk of HCC in patients with chronic hepatitis B (CHB). We examined the relationship between serum total testosterone and HCC risk in male CHB patients with DM. Methods: We performed a retrospective cohort study of male CHB patients with DM between 2000 and 2017 using a territory-wide electronic health-care database in Hong Kong. DM was defined by use of anti-diabetic medications, hemoglobin A1c ≥ 6.5%, and/or fasting glucose ≥ 7 mmol/L in two measurements or ≥ 11.1 mmol/L in one measurement. Results: Of 928 male CHB patients with DM, 83 (8.9%) developed HCC at a median (interquartile range) of 10.7 (6.1-14.6) years. Higher testosterone was associated with an elevated risk of HCC (adjusted hazard ratio [aHR] per 1 SD increase 1.23, 95% confidence interval [CI] 1.03-1.46, P = 0.024). The upper tertile of testosterone (aHR 1.86, 95% CI 1.02-3.39, P = 0.043), but not middle tertile (aHR 0.84, 95% CI 0.41-1.69 P = 0.620), was associated with a higher risk of HCC than the lower tertile. The cumulative incidence (95% CI) of HCC at 5, 10, and 15 years was 4.4% (2.5-7.2%), 12.4% (8.7-16.7%), and 19.1% (14.2-24.5%), respectively, in patients in the upper tertile of testosterone. By subgroup analysis, the association between testosterone and HCC was stronger in patients aged ≥ 50 years and those not receiving antiviral therapy. Conclusion: Higher serum testosterone is associated with a higher incidence of HCC in male CHB patients with DM. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Scientific Publications | - |
dc.relation.isPartOf | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Elevated testosterone increases risk of hepatocellular carcinoma in men with chronic hepatitis B and diabetes mellitus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Terry Cheuk-Fung Yip | - |
dc.contributor.googleauthor | Grace Lai-Hung Wong | - |
dc.contributor.googleauthor | Henry Lik-Yuen Chan | - |
dc.contributor.googleauthor | Yee-Kit Tse | - |
dc.contributor.googleauthor | Lilian Yan Liang | - |
dc.contributor.googleauthor | Vicki Wing-Ki Hui | - |
dc.contributor.googleauthor | Hye Won Lee | - |
dc.contributor.googleauthor | Grace Chung-Yan Lui | - |
dc.contributor.googleauthor | Alice Pik-Shan Kong | - |
dc.contributor.googleauthor | Vincent Wai-Sun Wong | - |
dc.identifier.doi | 10.1111/jgh.15079 | - |
dc.contributor.localId | A03318 | - |
dc.relation.journalcode | J01417 | - |
dc.identifier.eissn | 1440-1746 | - |
dc.identifier.pmid | 32343449 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/jgh.15079 | - |
dc.subject.keyword | Diabetes mellitus | - |
dc.subject.keyword | Hepatitis B virus | - |
dc.subject.keyword | Liver neoplasms | - |
dc.subject.keyword | Sex hormones | - |
dc.contributor.alternativeName | Lee, Hye Won | - |
dc.contributor.affiliatedAuthor | 이혜원 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2210 | - |
dc.citation.endPage | 2219 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.35(12) : 2210-2219, 2020-12 | - |
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