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Two-Sample Mendelian Randomization Study of Lipid levels and Ischemic Heart Disease

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dc.contributor.author김현창-
dc.contributor.author지선하-
dc.contributor.author지선하-
dc.contributor.author정금지-
dc.date.accessioned2021-09-29T00:24:48Z-
dc.date.available2021-09-29T00:24:48Z-
dc.date.issued2020-10-
dc.identifier.issn1738-5520-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/183818-
dc.description.abstractBackground and objectives: Associations between blood lipids and risk of ischemic heart disease (IHD) have been reported in observational studies. However, due to confounding and reverse causation, observational studies are influenced by bias, thus their results show inconsistency in the effects of lipid levels on IHD. In this study, we evaluate whether lipid levels have an effect on the risk of IHD in a Korean population. Methods: A 2-sample Mendelian randomization (MR) study, using the genetic variants associated with lipid levels as the instrumental variables was performed. Genetic variants significantly associated with lipid concentrations were obtained from the Korean Genome and Epidemiology Study (n=35,000), and the same variants on IHD were obtained from the Korean Cancer Prevention Study-II (n=13,855). Inverse variance weighting (IVW), weighted median, and MR-Egger approaches were used to assess the causal association between lipid levels and IHD. Radial MR methods were applied to remove outliers subject to pleiotropic bias. Results: Causal association between low-density lipoprotein-cholesterol (LDL-C) and IHD was observed in the IVW method (odds ratio, 1.013; 95% confidence interval, 1.007-1.109). However, high-density lipoprotein-cholesterol (HDL-C) and triglyceride (TG) did not show causal association with IHD. In the Radial MR analysis of the relationship between HDL-C, TG and IHD, outliers were detected. Interestingly, after removing the outliers, a causal association between TG and IHD was found. Conclusions: High levels LDL-C and TG were causally associated with increased IHD risk in a Korean population, these results are potentially useful as evidence of a significant causal relationship.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish, Korean-
dc.publisherKorean Society of Circulation-
dc.relation.isPartOfKOREAN CIRCULATION JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleTwo-Sample Mendelian Randomization Study of Lipid levels and Ischemic Heart Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학교실)-
dc.contributor.googleauthorSu Hyun Lee-
dc.contributor.googleauthorJi Young Lee-
dc.contributor.googleauthorGuen Hui Kim-
dc.contributor.googleauthorKeum Ji Jung-
dc.contributor.googleauthorSunmi Lee-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorSun Ha Jee-
dc.identifier.doi10.4070/kcj.2020.0131-
dc.contributor.localIdA01142-
dc.contributor.localIdA03965-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ01952-
dc.identifier.eissn1738-5555-
dc.identifier.pmid32812402-
dc.subject.keywordIschemic heart disease-
dc.subject.keywordLipid-
dc.subject.keywordMendelian randomization analysis-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.affiliatedAuthor김현창-
dc.contributor.affiliatedAuthor지선하-
dc.contributor.affiliatedAuthor지선하-
dc.citation.volume50-
dc.citation.number10-
dc.citation.startPage940-
dc.citation.endPage948-
dc.identifier.bibliographicCitationKOREAN CIRCULATION JOURNAL, Vol.50(10) : 940-948, 2020-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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