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Long-term compensation of renal function after donor nephrectomy

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dc.contributor.author김명수-
dc.contributor.author김수진-
dc.contributor.author김순일-
dc.contributor.author김유선-
dc.contributor.author이재근-
dc.contributor.author이주한-
dc.contributor.author주동진-
dc.contributor.author허규하-
dc.date.accessioned2021-09-29T00:23:37Z-
dc.date.available2021-09-29T00:23:37Z-
dc.date.issued2020-06-
dc.identifier.issn1298-1711-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/183806-
dc.description.abstractBackground: Living donors are the major source of kidneys in countries with a shortage of deceased donors. Kidney donation after careful donor selection is generally accepted as a safe procedure, but the physiologic consequences after donor nephrectomy are not fully verified. In this study we retrospectively reviewed the renal function of the residual kidney in living donors. Methods: Post-nephrectomy laboratory data of 1,175 living donors (60.7%) from 1,933 living donors who received uninephrectomy from January 1999 to December 2017 at Yonsei University, Severance Hospital, Korea were retrospectively collected. Post-nephrectomy renal function was monitored by the relative ratio of estimated glomerular filtration rate (e-GFR; pre-nephrectomy e-GFR ratio vs. post-nephrectomy e-GFR) that was calculated by the Modification of Diet in Renal Disease formula. Results: During 36.3±37.6 months of mean follow-up, two cases (0.17%, 2/1,175) of renal failure developed. The mean e-GFR decreased to 64.3±14.2 mL/min/1.73 m2 immediately after nephrectomy from 99.2±19.9 mL/min/1.73 m2 of the pre-nephrectomy e-GFR. Early decrement of e-GFR was prominent in male and obese donors (body mass index >25 kg/m2, P<0.05). The e-GFR ratio increased according to post-nephrectomy duration, and the mean increment degree of e-GFR ratio after nephrectomy calculated by linear regression analysis was 1.94% per year. Unlike the early decrement of e-GFR ratio after nephrectomy, donor factors such as degree of obesity and donor sex did not affect the late increment of e-GFR ratio after nephrectomy (P>0.05). Conclusions: Our data showed that long-term compensation of the renal function after nephrectomy occurs independently of preoperative donor characteristics.-
dc.description.statementOfResponsibilityopen-
dc.languageJournal of the Korean Society for Transplantation-
dc.publisherJournal of the Korean Society for Transplantation-
dc.relation.isPartOfJournal of the Korean Society for Transplantation-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleLong-term compensation of renal function after donor nephrectomy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorYong Pyo Lee-
dc.contributor.googleauthorSoo Jin Kim-
dc.contributor.googleauthorJuhan Lee-
dc.contributor.googleauthorJae Geun Lee-
dc.contributor.googleauthorKyu Ha Huh-
dc.contributor.googleauthorDong Jin Joo-
dc.contributor.googleauthorSoon Il Kim-
dc.contributor.googleauthorYu Seun Kim-
dc.contributor.googleauthorMyoung Soo Kim-
dc.identifier.doi10.4285/kjt.2020.34.2.84-
dc.contributor.localIdA00424-
dc.contributor.localIdA00636-
dc.contributor.localIdA00649-
dc.contributor.localIdA00785-
dc.contributor.localIdA03068-
dc.contributor.localIdA03163-
dc.contributor.localIdA03948-
dc.contributor.localIdA04344-
dc.relation.journalcodeJ01858-
dc.identifier.eissn2508-2604-
dc.subject.keywordGlomerular filtration rate-
dc.subject.keywordNephrectomy-
dc.subject.keywordLiving donors-
dc.subject.keywordKidney transplantation-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.affiliatedAuthor김명수-
dc.contributor.affiliatedAuthor김수진-
dc.contributor.affiliatedAuthor김순일-
dc.contributor.affiliatedAuthor김유선-
dc.contributor.affiliatedAuthor이재근-
dc.contributor.affiliatedAuthor이주한-
dc.contributor.affiliatedAuthor주동진-
dc.contributor.affiliatedAuthor허규하-
dc.citation.volume34-
dc.citation.number2-
dc.citation.startPage84-
dc.citation.endPage91-
dc.identifier.bibliographicCitationJournal of the Korean Society for Transplantation, Vol.34(2) : 84-91, 2020-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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