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Efficacy of Rhino-Protect ointment after endoscopic sinus surgery: a prospective, randomized, multicenter study

Authors
 Kyu-Sup Cho  ;  Soo Whan Kim  ;  Jin Kook Kim  ;  Chang-Hoon Kim 
Citation
 EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, Vol.278(1) : 109-115, 2021-01 
Journal Title
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
ISSN
 0937-4477 
Issue Date
2021-01
MeSH
Adult ; Aged ; Chronic Disease ; Endoscopy / adverse effects* ; Female ; Humans ; Male ; Middle Aged ; Ointments / therapeutic use* ; Otorhinolaryngologic Surgical Procedures / adverse effects* ; Paranasal Sinuses / surgery* ; Postoperative Complications / prevention & control ; Prospective Studies ; Rhinitis / drug therapy ; Rhinitis / surgery ; Sinusitis / surgery* ; Treatment Outcome
Keywords
Dr. Theiss Rhino-Protect® PRS ; Endoscopic sinus surgery ; Nose ; Postoperative care ; Wound healing
Abstract
Objective: Blocking airflow into the sinonasal cavity after surgery may help to keep the cavity moist and thus decrease postoperative crusting. Here we investigated the efficacy of Rhino-Protect ointment following endoscopic sinus surgery (ESS).

Subjects and methods: A total of 93 patients with chronic rhinosinusitis who underwent identical ESS were enrolled. After surgery, all patients were instructed to perform nasal saline irrigation and deliver a nasal spray to each nostril, then to apply Rhino-Protect ointment to one nostril only; the other nostril served as a control. Subjective symptoms, postoperative Lund-Kennedy (LK) endoscopic scores, and adverse reactions 14 and 28 days after treatment were evaluated.

Results: The Rhino-Protect ointment significantly reduced pain (p = 0.015 at 28 days), dryness (p = 0.009 at 14 days and p = 0.045 at 28 days), and crusting (p = 0.047 at 14 days), and was associated with significantly lower LK scores 14 and 28 days after treatment (p = 0.037 and p = 0.007, respectively). Statistically significant differences were noted in the LK edema subscore at 14 days (p = 0.043) and in LK crusting subscores at 14 and 28 days (p = 0.005 and p = 0.006, respectively). No patient reported any serious adverse event associated with Rhino-Protect use.

Conclusion: Applying Rhino-Protect after ESS significantly reduced the formation of edema and crusts, leading to improving the patients' discomfort for pain, dryness, and crust.
Full Text
https://link.springer.com/article/10.1007/s00405-020-06265-4
DOI
10.1007/s00405-020-06265-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183798
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