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사지 연장술에서 Bromodeoxyuridine Monoclonal Antibody를 이용한 근섬유 분열의 축적
DC Field | Value | Language |
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dc.contributor.author | 양규현 | - |
dc.date.accessioned | 2021-09-28T08:38:31Z | - |
dc.date.available | 2021-09-28T08:38:31Z | - |
dc.date.issued | 1996-04 | - |
dc.identifier.issn | 1226-2102 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183755 | - |
dc.description.abstract | Soft tissue related complications are quite frequent in limb lengthening. Muscle fibers may proliferate or regenerate after stretching injury over 10-20% of their original length. However, the cells which are engaged in this phenomenon are not confirmed yet. We chased the S-phase cells (phase for DNA replication) in the posterior leg muscle during limb lengthening by immunohistochemical technique. We lengthened the tibiae of fifteen New Zealand white rabbits. We divided them into three groups and each group is consisted of five rabbits. In group 1, we lengthened the left tibiae by 10% of their original length, in Group 2, 20%, and in group, 3, 25%, respectively, At the end of lengthening posterior muscles of lengthened left side and of controlled right side were fixed and processed for Immunohistochemical staining which could detect the incorporation of bromodeoxyuridine(BDU). Labelling index(LI:% of positively stained S-phase nuclei) of group 1 was zero. LI of groups for more than 20% lengthening (sum of group 2 and 3) was statistically significant. In conclusion, nuclei around or within the muscle tissue are in S-phase during limb lengthening which means proliferation of the muscle fivers or of the certain cells that abut muscle fibers. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한정형외과학회 | - |
dc.relation.isPartOf | Journal of the Korean Orthopaedic Association(대한정형외과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 사지 연장술에서 Bromodeoxyuridine Monoclonal Antibody를 이용한 근섬유 분열의 축적 | - |
dc.title.alternative | Detection of the Proliferation of Muscle Fibers During Limb Lengthening by Monoclonal Antibody to Bromodeoxyuridine | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학교실) | - |
dc.contributor.googleauthor | 박희완 | - |
dc.contributor.googleauthor | 양규현 | - |
dc.contributor.googleauthor | 강동민 | - |
dc.contributor.localId | A02282 | - |
dc.relation.journalcode | J01839 | - |
dc.identifier.eissn | 2005-8918 | - |
dc.subject.keyword | Muscle | - |
dc.subject.keyword | Proliferation | - |
dc.subject.keyword | Limb lengthening | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.contributor.alternativeName | Yang, Kyu Hyun | - |
dc.contributor.affiliatedAuthor | 양규현 | - |
dc.citation.volume | 31 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 265 | - |
dc.citation.endPage | 269 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Orthopaedic Association (대한정형외과학회지), Vol.31(2) : 265-269, 1996-04 | - |
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