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극저출생체중아에서 뇌성마비 및 발달지연 관련 고위험요인의 분석

Other Titles
 Risk Factors of Cerebral Palsy and Delayed Development in Very Low Birth Weight(VLBW) Infants 
Authors
 장혜영  ;  남궁란  ;  김정년  ;  박창일  ;  신지철  ;  신동천  ;  박민수  ;  박국인  ;  이철  ;  한동관 
Citation
 Korean Journal of Perinatology (대한주산의학회잡지), Vol.7(4) : 425-430, 1996-12 
Journal Title
Korean Journal of Perinatology(대한주산의학회잡지)
ISSN
 1229-2605 
Issue Date
1996-12
Abstract
Although the recent development of prenatal and neonatal intensive care have increased the survival rate of premature infants, the incidence of cerebral palsy(CP) is increasing due to the increased survival of very tiny, initially ill. infants. Screening criteria for cerebral palsy and delayed development(DD) is needed to perform an early diagnosis and treatment for CP in high risk infants.
The purpose of this study is to identify the risk factors of cerebral palsy and delayed development in VLBW infants. We performed a case-control study in 19 VL-BW infants who developed cerebral palsy and delayed development at 1 year of post-conceptional age. For control group, we selected 59 VLBW infants who showed normal development at 1 year of postconceptional age.
In univariate analysis, factors associated with an increased risk of CP and DD were chorioamnionitis/premature rupture of membrane (PROM) (OR 3.03, p=0.04), resuscitation after birth(OR 3.19, p=0.03), and periventricular leukomalacia(PVL)(OR 12.85, p=0.01). In multivariate logistic regression analysis, a significant factor associated with an increased risk of CP and DD was PVL(OR 13.2 ; 95 % CI 2.5-69.5, p =0.002). In multivariate logistic regression analysis after adjustment for gestational age and birth weight, a factor associated with an increased risk of CP and DD was PVL(OR 9.4 ; 95% Cl 2.0-44.9, p=0.005).
In conclusion, the only significant risk factor of cerebral palsy and delayed development in VLBW infants is periventricular leukomalacia. The VLBW infants with PVL should be on the careful follow-tip program after hospital discharge from neonatal intensive care unit to evaluate the early diagnosis and possible early treatment for CP and DD.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Namgung, Ran(남궁란) ORCID logo https://orcid.org/0000-0001-7182-9535
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Park, Chang Il(박창일)
Shin, Dong Chun(신동천) ORCID logo https://orcid.org/0000-0003-4252-2280
Shin, Ji Cheol(신지철) ORCID logo https://orcid.org/0000-0002-1133-1361
Lee, Chul(이철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183747
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