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Increased serum interleukin-10 level in Kawasaki disease

Authors
 Dong Soo Kim  ;  Hong Kyu Lee  ;  Geun Woong Noh  ;  Soon Il Lee  ;  Ki Young Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.37(2) : 125-130, 1996-04 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
1996-04
MeSH
Child ; Child, Preschool ; Female ; Humans ; Infant ; Interleukin-10 / blood* ; Interleukin-12 / blood ; Interleukin-4 / blood ; Male ; Mucocutaneous Lymph Node Syndrome / blood ; Mucocutaneous Lymph Node Syndrome / immunology*
Abstract
Serum IL-10 level in Kawasaki disease(KD) was tested. In the KD patients' sera during the acute phase, the levels of IL-10 were markedly elevated (122.0 ± 39.1 pg/ml) compared to 3.7 ± 1.7 pg/ml in the control subjects (p< 0.001). The serum IL-10 levels remained elevated in the subacute phase (16. 7 ± 9.7 pg/ml, p< 0.001) and were restored to the normal levels(7.9 ± 3.9 pg/ml) during the convalescent phase. In the patients with acute febrile disease, the serum IL-10 level increased significantly (34.4 ± 14.1 pg/ml, p< 0.001) compared to that of the age-matched control subjects, but were not as high as in acute phase of KD(p< 0.005). This increase in serum IL-10 levels in KD may contribute to the up-regulation of humoral immunity and to the down-regulation of acute inflammation due to an increase in proinflammatory cytokines.
Files in This Item:
T199602513.pdf Download
DOI
10.3349/ymj.1996.37.2.125
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183712
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