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환경성발암물질의 용량-반응모델의 이론적 근거와 응용에 관한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신동천 | - |
dc.date.accessioned | 2021-09-28T08:29:54Z | - |
dc.date.available | 2021-09-28T08:29:54Z | - |
dc.date.issued | 1996-03 | - |
dc.identifier.issn | 0254-5985 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183679 | - |
dc.description.abstract | This study described methods ´-to ` predict human health risk associated with exposure to environmental carcinogens using animal bioassay data. Also, biological´ assumption for various dose-response models were reviewed. To illustrate the process of risk estimate using relevant dose-response models such as Log-normal, Mantel-Bryan, Weibull and Multistage model, we used four animal carcinogenesis bioassy data of chloroform and chloroform concentrations of tap water measured in large cities of Korea from 1987 to 1995. As a result, in the case of using average concentration in exposure data and 95% upper bond unit risk of Multistge model, excess cancer risk(RISK I) was about 1.0 x 10-6, in the case of using probability distribution of cumulative exposure data and unit risks, those risks(RISK 11) which were simulated by Monte-Carlo analysis were about 2.4 x 10fi and 7.9 x 10-5 at 50 and 95 percentile, respectively. Therefore risk´ estimated by Monte-Carlo analysis using probability distribution of input variables may be more conservative. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한예방의학회 | - |
dc.relation.isPartOf | Korean Journal of Preventive Medicine(예방의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 환경성발암물질의 용량-반응모델의 이론적 근거와 응용에 관한 연구 | - |
dc.title.alternative | Scientific rational and applicability of dose-response models for environmental carcinogens | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine and Public Health (예방의학교실) | - |
dc.contributor.googleauthor | 신동천 | - |
dc.contributor.googleauthor | 정용 | - |
dc.contributor.googleauthor | 김종만 | - |
dc.contributor.googleauthor | 이성임 | - |
dc.contributor.googleauthor | 황만식 | - |
dc.contributor.localId | A02096 | - |
dc.relation.journalcode | J02105 | - |
dc.contributor.alternativeName | Shin, Dong Chun | - |
dc.contributor.affiliatedAuthor | 신동천 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 27 | - |
dc.citation.endPage | 41 | - |
dc.identifier.bibliographicCitation | Korean Journal of Preventive Medicine (예방의학회지), Vol.29(1) : 27-41, 1996-03 | - |
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