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Production of interferon-gamma and interleukin-4 by splenocytes in mice infected with Paragonimus westermani
DC Field | Value | Language |
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dc.contributor.author | 신명헌 | - |
dc.date.accessioned | 2021-09-28T08:27:31Z | - |
dc.date.available | 2021-09-28T08:27:31Z | - |
dc.date.issued | 1996-09 | - |
dc.identifier.issn | 0023-4001 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183654 | - |
dc.description.abstract | The TH cytokine responses of spleen cells stimulated with Con A from mice infected with Paragonimus westermani were examined. The spleen cell culture supernatants were assayed for TH1-specific IFN-γ and TH2-specific IL-4. Cytokine responses for IL-4 peaked at three days (410 ± 60.9 pg/ml), persisted at a high level until the second week (343 ± 59.0 pg/ml), and then decreased slowly four and six weeks after infection. IFN-γ production by splenocytes only increased during the first week (151 ± 32.3 pg/ml) and declined abruptly after the second week of infection. IFN-γ production by splenocytes of infected mice was not observed during the sixth week of infection. In addition, serum IL-4 and IFN-γ were measured. Serum IL-4 was not detected in substantial quantity until four to six weeks after infection. The time course of serum IL-4 was not correlated with that of IL-4 production by splenocytes. Serum IFN-γ was undetectable during the entire course of infection. These results suggest that TH2 cytokine responses, rather than TH1, predominate in mice infected with P. westermani. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society for Parasitology | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Production of interferon-gamma and interleukin-4 by splenocytes in mice infected with Paragonimus westermani | - |
dc.title.alternative | 폐흡충 감염 마우스에 있어서 비장세포에서 분비되는 interferon-γ 및 interleukin-4의 생산 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Tropica Medicine (열대의학교실) | - |
dc.contributor.googleauthor | Myeong-Heon SHIN | - |
dc.contributor.googleauthor | Duk-Young MIN | - |
dc.identifier.doi | 10.3347/kjp.1996.34.3.185 | - |
dc.contributor.localId | A02099 | - |
dc.relation.journalcode | J01957 | - |
dc.identifier.eissn | 1738-0006 | - |
dc.contributor.alternativeName | Shin, Myeong Heon | - |
dc.contributor.affiliatedAuthor | 신명헌 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 185 | - |
dc.citation.endPage | 189 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PARASITOLOGY, Vol.34(4) : 185-189, 1996-09 | - |
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