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Expression of epidermal growth factor receptor in carcinoma of the cervix

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dc.contributor.author김영태-
dc.contributor.author김재욱-
dc.date.accessioned2021-09-28T08:25:29Z-
dc.date.available2021-09-28T08:25:29Z-
dc.date.issued1996-02-
dc.identifier.issn0090-8258-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/183635-
dc.description.abstractIncreased expression of the epidermal growth factor receptor (EGFR) gene has been shown in a large number of tumors, generally indicating a more aggressive biological behavior of cancers than those with low or normal expression. The role of EGFR in the tumorigenesis of the uterine cervix has been poorly understood and controversial. In order to explore the relationship between EGFR status and cervical carcinoma, tissues were analyzed from 40 patients, each of whom had invasive cervical carcinoma prior to treatment, 20 patients with cervical intraepithelial neoplasia (CIN) and 10 control cases who underwent hysterectomy due to benign gynecological disease at Yonsei University College of Medicine. We measured EGFR with an enzyme-linked immunosorbent assay which was a sandwich type using a mouse monoclonal capture antibody and a rabbit antiserum as detector. Patients with invasive cervical cancer were found to have significantly higher median EGFR expression than either the patients with CIN (P= 0.002) or the control (P= 0.001), respectively. However, there was no significant difference in EGFR status between CIN and the control groups. Overexpression of EGFR was found in 29 of 40 (72.5%) invasive cervical cancers and in 5 of 20 (25%) CIN patients. In invasive cervical cancer, no significant difference in EGFR levels was noted when stratified according to age, menopausal status, histological cell type, or clinical stage. With regard to tumor size, lesions of 4 cm and larger had significantly higher receptor levels than those lesions under 4 cm (P= 0.003). Even though quantitative EGFR status did not correlate with other prognostic parameters except tumor size, our results were consistent with the concept that EGFR may play an important role in malignant transformation and tumorigenesis in cervical cancer.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAcademic Press-
dc.relation.isPartOfGYNECOLOGIC ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma / metabolism*-
dc.subject.MESHCarcinoma / pathology-
dc.subject.MESHCervical Intraepithelial Neoplasia / metabolism*-
dc.subject.MESHCervical Intraepithelial Neoplasia / pathology-
dc.subject.MESHErbB Receptors / metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoenzyme Techniques-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHUterine Cervical Neoplasms / metabolism*-
dc.subject.MESHUterine Cervical Neoplasms / pathology-
dc.titleExpression of epidermal growth factor receptor in carcinoma of the cervix-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorJae Wook Kim-
dc.contributor.googleauthorYoung Tae Kim-
dc.contributor.googleauthorDong Kyu Kim-
dc.contributor.googleauthorChan Ho Song-
dc.contributor.googleauthorJung Woon Lee-
dc.identifier.doi10.1006/gyno.1996.0039-
dc.contributor.localIdA00729-
dc.contributor.localIdA00866-
dc.relation.journalcodeJ00956-
dc.identifier.eissn1095-6859-
dc.identifier.pmid8631552-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0090825896900396-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.affiliatedAuthor김영태-
dc.contributor.affiliatedAuthor김재욱-
dc.citation.volume60-
dc.citation.number2-
dc.citation.startPage283-
dc.citation.endPage287-
dc.identifier.bibliographicCitationGYNECOLOGIC ONCOLOGY, Vol.60(2) : 283-287, 1996-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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