자궁내막암에서 EIA Monoclonal Assay를 이용한 Estrogen 및 Progesterone 수용체 측정의 임상적 유용성

Abstract

Cytosolic estrogen and progesterone receptors(ER and PR) are present in female genital organs including endometrium, myometrium, cervix, fallopian tubes, and ovaries. The concentrations of receptors definitely aid in the selection of hormonal chemotherapy in paitnets with endometrial cancer and also hepls predict the behavior of the tumor. Even though several methods are available for detections of steroid hormone receptors, by employing the enzyme immunoassay, we have evaluated the cytosolic ER and PR status in the patients with endometrial cancer. Because this assay has several advantages, it allows direct antigenic determination of the receptors and reduction of interlaboratory variations and it can detect the receptor site whether or not it is occupied by endogenous estrogen. It requires only a small volume of tumor tissue and can be performed in a short period. ER and PR concentration was measured in 23 endometrial cancers and 16 controls. ER and PR were positive in 86% and 91% of endometrial cancers. In endometrial cancer, ER and PR status is significant with clinical stage and may predict limited prognostic significance.