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Nucleotide sequence variation in the hypervariable region of the hepatitis C virus in the sera of chronic hepatitis C patients undergoing controlled interferon-α therapy
DC Field | Value | Language |
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dc.contributor.author | 김현숙 | - |
dc.date.accessioned | 2021-09-28T08:21:26Z | - |
dc.date.available | 2021-09-28T08:21:26Z | - |
dc.date.issued | 1996-06 | - |
dc.identifier.issn | 0146-6615 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183595 | - |
dc.description.abstract | Ten patients with hepatitis C virus (HCV) infection (experimental group) were treated with interferon-α (IF-α). Dosage was six million units per day for one week and then three times a week for another six months. Seven HCV-infected patients (control group) did not receive IF-α therapy. The hypervariable region (HVR) of HCV in the sera of patients was amplified by reverse transcription-polymerase chain reaction (RT-PCR), and the variation of amino acid sequence in this region was determined. Serum alanine aminotransferase (ALT) activities in five patients treated for six months with IF-α fell to the normal range, when HCV was not detected in the sera of three patients. The nucleotide sequence variation in HVR of HCV in the sera of five patients who responded well to the IF-α therapy was relatively less than that in another five patients who did not respond to IF-α therapy and those in the control patients. These results indicate that the effectiveness of IF-α therapy was related to the sequence variation of HVR of HCV. This may have resulted from the selection pressure by humoral antibodies directed to HVR of HCV. It is concluded that the higher rate of sequence variation in HVR of HCV was compatible with a lower degree of effectiveness of IF-α therapy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | JOURNAL OF MEDICAL VIROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Alanine Transaminase / blood | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | Chronic Disease | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Hepacivirus / chemistry* | - |
dc.subject.MESH | Hepatitis C / blood* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interferon-alpha / therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Mutation | - |
dc.title | Nucleotide sequence variation in the hypervariable region of the hepatitis C virus in the sera of chronic hepatitis C patients undergoing controlled interferon-α therapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Byung-Il Yeh | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Seung-Hee Oh | - |
dc.contributor.googleauthor | Hyon-Suk Kim | - |
dc.contributor.googleauthor | Suk-Hyun Hong | - |
dc.contributor.googleauthor | Sang-Hwan Oh | - |
dc.contributor.googleauthor | Yoon-Soo Kim | - |
dc.identifier.doi | 10.1002/(SICI)1096-9071(199606)49:2<95::AID-JMV5>3.0.CO;2-E | - |
dc.contributor.localId | A01117 | - |
dc.relation.journalcode | J01587 | - |
dc.identifier.eissn | 1096-9071 | - |
dc.identifier.pmid | 8991943 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-9071(199606)49:2%3C95::AID-JMV5%3E3.0.CO;2-E/abstract | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.affiliatedAuthor | 김현숙 | - |
dc.citation.volume | 49 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 102 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICAL VIROLOGY, Vol.49(2) : 95-102, 1996-06 | - |
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