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Sequential production and activation of matrix-metalloproteinase-9 (MMP-9) with breast cancer progression
DC Field | Value | Language |
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dc.contributor.author | 노재경 | - |
dc.date.accessioned | 2021-09-28T08:07:59Z | - |
dc.date.available | 2021-09-28T08:07:59Z | - |
dc.date.issued | 1996-04 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183437 | - |
dc.description.abstract | The degradation of the basement membrane by matrix-metalloproteinase(MMP) and serine protease is a critical pointin tumor invasion and metastasis. We measured theactivity of MMP-9 from 28 normal, 12 benignand 126 breast cancer tissues using gelatin zymographywith an image analysis system. ProMMP-9 was expressedin 17.5% of the cancer patients compared to2.5% in 40 non-cancerous tissues (p=0.014).The mature form of MMP-9 (82 kD) wasexpressed only in T2–T4 stages. During the earlyphase of breast cancer (DCIS and T1 stage)progression, only production of proMMP-9 increased. However, asthe cancer grew or invaded skin (T2–T4), orwith lymphovascular permeation, both production and activation ofMMP-9 increased. In conclusion, proMMP-9 production was themain cause of increased MMP-9 activity during theearly phase, while both production and activation increasedin the late phase of breast cancer. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Kluwer Academic | - |
dc.relation.isPartOf | BREAST CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Breast Neoplasms / enzymology* | - |
dc.subject.MESH | Breast Neoplasms / pathology* | - |
dc.subject.MESH | Collagenases / biosynthesis* | - |
dc.subject.MESH | Collagenases / metabolism* | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Enzyme Activation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Matrix Metalloproteinase 9 | - |
dc.title | Sequential production and activation of matrix-metalloproteinase-9 (MMP-9) with breast cancer progression | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Joo Hang Kim | - |
dc.contributor.googleauthor | Jae Kyung Roh | - |
dc.contributor.googleauthor | Kyong Sik Lee | - |
dc.contributor.googleauthor | Jin Sik Min | - |
dc.contributor.googleauthor | Byung Soo Kim | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.identifier.doi | 10.1023/A:1005701231871 | - |
dc.contributor.localId | A01290 | - |
dc.relation.journalcode | J00403 | - |
dc.identifier.eissn | 1573-7217 | - |
dc.identifier.pmid | 9131273 | - |
dc.identifier.url | http://link.springer.com/article/10.1023/A:1005701231871 | - |
dc.contributor.alternativeName | Roh, Jae Kyung | - |
dc.contributor.affiliatedAuthor | 노재경 | - |
dc.citation.volume | 42 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 175 | - |
dc.citation.endPage | 181 | - |
dc.identifier.bibliographicCitation | BREAST CANCER RESEARCH AND TREATMENT, Vol.42(2) : 175-181, 1996-04 | - |
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