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Pre-injury Treatment of Methylprednisolone in Experimental Spinal Cord Injury
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤도흠 | - |
dc.date.accessioned | 2021-09-28T08:04:27Z | - |
dc.date.available | 2021-09-28T08:04:27Z | - |
dc.date.issued | 1996-08 | - |
dc.identifier.issn | 1225-8245 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183395 | - |
dc.description.abstract | The purpose of this study was to establish whether pre-injury administration of the methylprednisolone sodium succinate(MP) is effective for the treatment of acute spinal cord injury in rat, as it has been demonstrated that high dose of MP is effective in the treatment of acute spinal cord injury. Spinal cord injury was made by dropping a rod weighing 10 gm from a height of 1.25, 2. 5, and 5.0cm onto the rat spinal cord at T-10, which had been exposed via laminectomy. In oder to determine the effectivness, single dose of 5. 15 and 30mg/kg of MP was administrated at 10 minute before injury. The primary outcome was 24-hour spinal cord lesion volume estimated from spinal cord Na+ and K+ shifts. Surprisingly, we failed to find any statistically significant preventive effect compare to control vehicle. Until this result is clearified, we recommend that acute pre-injury MP therapy be cautiously applied in operating room. The possible causes of this unexpected result are discussed. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한신경외과학회 | - |
dc.relation.isPartOf | Journal of Korean Neurosurgical Society(대한신경외과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Pre-injury Treatment of Methylprednisolone in Experimental Spinal Cord Injury | - |
dc.title.alternative | 실험동물의 척추손상에서 손상전 MP 투여의 효과 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | Do Heum Yoon | - |
dc.contributor.googleauthor | Young Soo Kim | - |
dc.contributor.googleauthor | Wise Young | - |
dc.contributor.localId | A02546 | - |
dc.relation.journalcode | J01521 | - |
dc.subject.keyword | Methylprednisolne | - |
dc.subject.keyword | Spinal cord injury | - |
dc.subject.keyword | Pre-injury treatment | - |
dc.subject.keyword | Rat | - |
dc.contributor.alternativeName | Yoon, Do Heum | - |
dc.contributor.affiliatedAuthor | 윤도흠 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1568 | - |
dc.citation.endPage | 1576 | - |
dc.identifier.bibliographicCitation | Journal of Korean Neurosurgical Society (대한신경외과학회지), Vol.25(8) : 1568-1576, 1996-08 | - |
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