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증후성 간질발작에 대한 radiosurgery의 효과

Other Titles
 Effect of Radiosurgery on Symptomatic Epilepsy 
 박용구  ;  이경회  ;  신형철  ;  김은영  ;  장진우  ;  정상섭 
 Journal of Korean Neurosurgical Society (대한신경외과학회지), Vol.25(10) : 1977-1981, 1996-10 
Journal Title
Journal of Korean Neurosurgical Society(대한신경외과학회지)
Issue Date
Radiosurgery ; Gamma knife ; Epilepsy ; Seizure ; Arteriovenous malformation ; Brain tumor
It has been suggested that focused radiation generated and delivered by several means can reduce seizure frequency in idiopathic and lesional epilepsy. Stereotactic radiosurgery has become one of ti,e most acceptable means of treating intracranial arteriovenous malformations or tumors, and has been found to have an effect on seizures serendipitously while being used for other indications. Between 1988 and 1996; 595 lesions of 490 patients with AVM or brain tumors were treated with radiosurgery(55 by Linear accelerator, 545 by Gamma Knife). Lesional epilepsy was accompanied in 73 patients before treatment. Among them. 25 cases had chronic repeated seizure (more than 4 times-per 1 year over 1 year) and were on anticonvulsants before treatment, and were followed longer than 1 year. The lesion volume was 2.9-27.9cc(mean, 16.2±15.1cc). The estimated dose was 10-26.4Gy(mean, 15.9±4Gy) at. the margin. Mean follow-up is 20 months(from 12 to 42.3). Epilepsy worsened transiently in 2 cases due´ to radiation induced imaging. changes that were improved with steroid medication. Four cases were seizure-free after treatment. Six patients presented a reduction of seizure frequencies by more than 50%. Reduction of the lesion volume did not correlate with the reduction of seizures. However. the mean volume of preoperative lesions in improved cases(19.3±2.8cc) was larger than in unimproved cases(13.1±8.2cc) and it was the only statistically significant variable. It seems that radiosurgery employing a standard neuro-oncological dose can improve seizures and this effect is not related to the lesion volume reduction.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Gou(박용구)
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