Cited 0 times in
Sequential activation and production of matrix metalloproteinase-2 during breast cancer progression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김주항 | - |
dc.contributor.author | 노재경 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 정현철 | - |
dc.date.accessioned | 2021-09-28T07:57:35Z | - |
dc.date.available | 2021-09-28T07:57:35Z | - |
dc.date.issued | 1996-11 | - |
dc.identifier.issn | 0262-0898 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183307 | - |
dc.description.abstract | The proteolytic processes are thought to be the critical point in tumor invasion and metastasis, mainly by matrix metalloproteinases (MMPs) and serine proteases. We measured the activity of MMP-2 from 28 normal, 12 benign and 126 breast cancer tissues using gelatin zymography. Inactive MMP-2 (72 kD) was expressed in 53.6% of the normal and 66.6% of the cancer tissues, respectively (P = 0.77), while active MMP-2 (62 kD) was expressed in 28.6% and 73.0%, respectively (P = 0.003). The enzymatic activity of active MMP-2 (62 kD) measured in the gel band area was 4.0 +/- 7.2 mm2 in normal breasts, 7.7 +/- 9.8 mm2 in benign breast diseases, 9.5 +/- 8.5 mm2 in ductal carcinoma in situ (DCIS), and 12.0 +/- 13.7 mm2 in invasive cancers. The MMP-2 activation ratio (62 kD/62 kD + 72 kD) was 0.12 +/- 0.18 in normal tissues, 0.10 +/- 0.20 in benign diseases, 0.61 +/- 0.22 in DCIS, and 0.50 +/- 0.28 in invasive cancers. In conclusion, MMP-2 activation was the main cause of the increased 62 kD MMP-2 activity during the early phase of breast cancer, while production of MMP-2 supplemented the increased 62 kD activity in the late phase. We suggest, therefore, that these differential expressions of MMP-2 activation and production during the different stages of breast cancer progression are potential therapeutic targets for biological or gene therapy under the concept of stage-oriented cancer treatment. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Kluwer Academic Publishers | - |
dc.relation.isPartOf | CLINICAL & EXPERIMENTAL METASTASIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Breast / enzymology* | - |
dc.subject.MESH | Breast Diseases / enzymology | - |
dc.subject.MESH | Breast Neoplasms / enzymology* | - |
dc.subject.MESH | Breast Neoplasms / pathology | - |
dc.subject.MESH | Carcinoma, Ductal, Breast / enzymology | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Enzyme Activation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gelatinases / metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Matrix Metalloproteinase 2 | - |
dc.subject.MESH | Metalloendopeptidases / metabolism* | - |
dc.subject.MESH | Neoplasm Proteins / metabolism* | - |
dc.subject.MESH | Prognosis | - |
dc.title | Sequential activation and production of matrix metalloproteinase-2 during breast cancer progression | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Kyong Sik Lee | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Sea Joong Kim | - |
dc.contributor.googleauthor | Joo Hang Kim | - |
dc.contributor.googleauthor | Jae Kyong Roh | - |
dc.contributor.googleauthor | Byung Soo Kim | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.identifier.doi | 10.1007/BF00115111 | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A03773 | - |
dc.relation.journalcode | J00544 | - |
dc.identifier.eissn | 1573-7276 | - |
dc.identifier.pmid | 8970581 | - |
dc.identifier.url | http://link.springer.com/article/10.1007/BF00115111 | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | 김주항 | - |
dc.contributor.affiliatedAuthor | 노재경 | - |
dc.contributor.affiliatedAuthor | 라선영 | - |
dc.contributor.affiliatedAuthor | 정현철 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 512 | - |
dc.citation.endPage | 519 | - |
dc.identifier.bibliographicCitation | CLINICAL & EXPERIMENTAL METASTASIS, Vol.14(6) : 512-519, 1996-11 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.