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류마티스양 관절염에서 CD20dim T 세포의 발현
DC Field | Value | Language |
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dc.contributor.author | 김현숙 | - |
dc.contributor.author | 이수곤 | - |
dc.date.accessioned | 2021-09-28T07:56:43Z | - |
dc.date.available | 2021-09-28T07:56:43Z | - |
dc.date.issued | 1996-07 | - |
dc.identifier.issn | 1226-8070 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183296 | - |
dc.description.abstract | Objective : This study was designed to investigate CD20dim expression on T cells between healthy control subjects and rheumatoid arthritis patients and to investigate the association between CD20dim T cells and clinical manifestations in rheumatoid arthriris. Methods : Peripheral bloods from twenty seven healthy controls and twenty six rheumatoid patients were evaluated by dual color immunophenotyping. We used IgG1a and IgG2a for negative control, then divided T cells and B cells on Cd3/CD19 combination. And we evaluated two subpopulation CD5+CD20did T cell (CD20dim T cell) and CD5+CD20bright cell (CD5 B cell) on CD5/20 combination for comparison. In order to correlate the CD20dim T cell data with patient's clinical status, patients characteristics such as age, disease duration, morning stiffness, rheumatoid factor (RF), and antinuclear antibody (ANA) were reviewed. Results : The mean percent positivity of T cells (CD3) and B cells (CD19) in 27 healthy control donors was 63.2±7.7%, and 11.4%±2.6%. The mean percentages of CD20dim T cell and CD5 B cell (Leul) were 2.3±1.0% and 1.4±0.9% and upper limit of reference values of CD20dim T cells and CD5 B cells (Leul) that calculated from normal healthy controls were 4.3% and 3.2%. Compared with healthy controls, CD20dim T cells were significantly elevated in total patient groups (4.4±2.7%, p<0.01). and significantly increased more than upper limit of reference values in eleven of 26 patients. Compared with CD20dim T cells according to disease duration, disease duration of most patients (10/11) with elevated CD20dim T cell were less than 2 years. Conclusion : The results indicated that CD20dim T cells were expressed at low levels in healthy controls but elevated levels of CD20dim T cells in rheumatoid arthritis patients were observed and close relationship to CD20dim T cells expression and disease duration was noted. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한류마티스학회 | - |
dc.relation.isPartOf | Journal of the Korean Rheumatism Association(대한류마티스학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 류마티스양 관절염에서 CD20dim T 세포의 발현 | - |
dc.title.alternative | CD20dim T Cell Expression in Rheumatoid Arthritis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | 이종욱 | - |
dc.contributor.googleauthor | 이정운 | - |
dc.contributor.googleauthor | 김현숙 | - |
dc.contributor.googleauthor | 권오헌 | - |
dc.contributor.googleauthor | 이수곤 | - |
dc.contributor.localId | A01117 | - |
dc.contributor.localId | A02889 | - |
dc.relation.journalcode | J01847 | - |
dc.subject.keyword | CD20dim T cell | - |
dc.subject.keyword | Rheumatoid arthiritis | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.affiliatedAuthor | 김현숙 | - |
dc.contributor.affiliatedAuthor | 이수곤 | - |
dc.citation.volume | 3 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 179 | - |
dc.citation.endPage | 186 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Rheumatism Association (대한류마티스학회지), Vol.3(2) : 179-186, 1996-07 | - |
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