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Gastric Cancer in Young Patients Who Underwent Curative Resection: Comparative Study with Older Patients

Authors
 Choi, Jin-Hyuk  ;  Chung, Hyun Cheol  ;  Yoo, Nae Chun  ;  Lee, Hye Ran  ;  Lee, Kyung Hee  ;  Kim, Joo-Hang  ;  Roh, Jae Kyung  ;  Park, Cheong Soo  ;  Min, Jin Sik  ;  Lee, Kyong Sik  ;  Kim, Byung Soo  ;  Lim, Ho Yeong 
Citation
 AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, Vol.19(1) : 45-48, 1996-02 
Journal Title
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
ISSN
 0277-3732 
Issue Date
1996-02
MeSH
Adult ; Age Distribution ; Age Factors ; Antineoplastic Combined Chemotherapy Protocols / therapeutic use ; Chemotherapy, Adjuvant ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Sex Distribution ; Stomach Neoplasms / drug therapy ; Stomach Neoplasms / mortality ; Stomach Neoplasms / pathology ; Stomach Neoplasms / surgery* ; Survival Analysis
Abstract
Although several studies demonstrated the poor prognosis of young patients with gastric cancer, there were few reports about the survival of young patients who underwent radical surgery. We retrospectively reviewed the hospital records of 697 patients with curatively resected locally advanced gastric cancer to compare the pathologic findings and prognosis of young patients (aged <40 years; 91 patients) with those of older (aged >=40 years; 606 patients) patients. There were no significant differences in location of tumors, Borrmann types, tumor invasion, and pathologic stage between both age groups. Despite the male predominance in older patients, the male-to-female ratio was nearly equal in young patients (p = 0.022). A significantly higher percentage of young patients showed poorly differentiated histology including signet ring cell and undifferentiated carcinoma than older patients (p < 0.0001). Adjuvant chemotherapy was more frequently performed in the young patients with a variety of different regimens (85.7 vs. 72.3%; p = 0.009). The 5-year overall survival rate revealed no statistically significant difference between the young and older patients (53.1 vs. 56.6%; p = 0.820). In conclusion, the young patients with curatively resected locally advanced gastric cancer showed similar survival compared to that of older patients.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000421-199602000-00010&LSLINK=80&D=ovft
DOI
10.1097/00000421-199602000-00010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hang(김주항)
Roh, Jae Kyung(노재경)
Yoo, Nae Choon(유내춘)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183213
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