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N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptor antagonists differentially suppress dorsal horn neuron responses to mechanical stimuli in rats with peripheral nerve injury
DC Field | Value | Language |
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dc.contributor.author | 임중우 | - |
dc.date.accessioned | 2021-09-28T07:49:46Z | - |
dc.date.available | 2021-09-28T07:49:46Z | - |
dc.date.issued | 1996-06 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183210 | - |
dc.description.abstract | The effects of iontophoretically ejected glutamate receptor antagonists on mechanically evoked responsiveness were examined on wide dynamic range (WDR) dorsal horn neurons in anesthetized rats that received a unilateral ligation of the L5 and L6 spinal nerves 10-15 days previously. Both brush- and pinch-evoked responses of dorsal horn neurons on the nerve-injured side were enhanced. N-Methyl-D-aspartate (NMDA) receptor antagonist, 2-amino-5-phosphonopentanoic acid (AP5), preferentially suppressed the enhanced pinch-evoked response, whereas (RS)-a-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptor selective antagonist, 6-nitro-7-sulphamoylbenzo(f)quinoxaline-2,3-dione (NBQX), preferentially attenuated the enhanced brush-evoked response. The results indicate that the enhanced responses to noxious and non-noxious peripheral inputs induced in WDR dorsal horn neurons following the nerve injury are mediated by activation of NMDA and AMPA receptors, respectively. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers Ireland | - |
dc.relation.isPartOf | NEUROSCIENCE LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | 2-Amino-5-phosphonovalerate / pharmacology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Electrophysiology | - |
dc.subject.MESH | Excitatory Amino Acid Agonists / administration & dosage | - |
dc.subject.MESH | Excitatory Amino Acid Agonists / pharmacology | - |
dc.subject.MESH | Excitatory Amino Acid Antagonists / pharmacology* | - |
dc.subject.MESH | Iontophoresis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | N-Methylaspartate / administration & dosage | - |
dc.subject.MESH | N-Methylaspartate / pharmacology | - |
dc.subject.MESH | Neurons / drug effects | - |
dc.subject.MESH | Neurons / physiology* | - |
dc.subject.MESH | Peripheral Nerve Injuries* | - |
dc.subject.MESH | Physical Stimulation | - |
dc.subject.MESH | Quinoxalines / pharmacology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors* | - |
dc.subject.MESH | Spinal Cord / drug effects | - |
dc.subject.MESH | Spinal Cord / physiology* | - |
dc.subject.MESH | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / administration & dosage | - |
dc.subject.MESH | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / pharmacology | - |
dc.title | N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptor antagonists differentially suppress dorsal horn neuron responses to mechanical stimuli in rats with peripheral nerve injury | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학교실) | - |
dc.contributor.googleauthor | Joong Woo Leem | - |
dc.contributor.googleauthor | Eun Jin Choi | - |
dc.contributor.googleauthor | Eun Sun Park | - |
dc.contributor.googleauthor | Kwang Se Paik | - |
dc.identifier.doi | 10.1016/0304-3940(96)12714-2 | - |
dc.contributor.localId | A03409 | - |
dc.relation.journalcode | J02364 | - |
dc.identifier.eissn | 1872-7972 | - |
dc.identifier.pmid | 8809842 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/0304394096127142 | - |
dc.contributor.alternativeName | Leem, Joong Woo | - |
dc.contributor.affiliatedAuthor | 임중우 | - |
dc.citation.volume | 211 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 37 | - |
dc.citation.endPage | 40 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE LETTERS, Vol.211(1) : 37-40, 1996-06 | - |
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