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Changes in intracellular Ca2+ concentration of rabbit coronary artery smooth muscle cell during ischemic cardioplegic period
DC Field | Value | Language |
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dc.contributor.author | 안덕선 | - |
dc.contributor.author | 이영호 | - |
dc.date.accessioned | 2021-09-28T07:48:52Z | - |
dc.date.available | 2021-09-28T07:48:52Z | - |
dc.date.issued | 1996-08 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183199 | - |
dc.description.abstract | To elucidate the possibility whether an elevation of intracellular Ca2+ concentration ([Ca2+]i) in rabbit coronary artery myocytes during ischemic cardioplegic period may serve as one of the mechanisms of the "no-reflow' phenomenon or not, the changes in [Ca2+]i were measured under ischemic cardioplegia conditions using a fluorescent Ca2+ indicator, fura 2/AM. When single cells were perfused with cardioplegic or ischemic cardioplegic solutions, [Ca2+]i was significantly increased and the degree of [Ca2+] elevation was further augmented by the ischemic cardioplegic solution. Pretreatment of a sarcoplasmic reticulum emptying agent, 20 mM caffeine, had no effect on ischemic cardioplegia-induced [Ca2+]i changes, but application of a Ca2+ channel blocker, 5 x 10-1M nifedipine, or an antagonist of Na+/Ca2+ exchange, 5 mM Ni2+, significantly inhibited the [Ca2+]i elevation, respectively. The magnitude of ischemic cardioplegia-induced [Ca2+]i elevation was dependent on the Ca2+ concentration of perfusate in the range of 0 and 25 mM. When Ni2+ was added to the reperfusion solution, recovery of ischemic cardioplegia-induced [Ca2+]i elevation was very rapid compared with the controls. It is concluded that ischemic cardioplegia-induced [Ca2+]i elevation may serve as one of the mechanisms of the "no-reflow' phenomenon in rabbit coronary artery smooth muscle cells. We propose that Na+/Ca2+ exchange may serve as a key function in ischemic cardioplegia-induced [Ca2+]i elevation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Arteries / metabolism | - |
dc.subject.MESH | Calcium / metabolism* | - |
dc.subject.MESH | Coronary Vessels / metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart Arrest, Induced* | - |
dc.subject.MESH | Intracellular Membranes / metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Muscle, Smooth, Vascular / metabolism* | - |
dc.subject.MESH | Muscle, Smooth, Vascular / pathology | - |
dc.subject.MESH | Myocardial Ischemia / metabolism* | - |
dc.subject.MESH | Myocardial Ischemia / pathology | - |
dc.subject.MESH | Osmolar Concentration | - |
dc.subject.MESH | Rabbits | - |
dc.title | Changes in intracellular Ca2+ concentration of rabbit coronary artery smooth muscle cell during ischemic cardioplegic period | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학교실) | - |
dc.contributor.googleauthor | Young Ho Lee | - |
dc.contributor.googleauthor | Gyu Bog Choi | - |
dc.contributor.googleauthor | Duck Sun Ahn | - |
dc.contributor.googleauthor | Bok Soon Kang | - |
dc.identifier.doi | 10.3349/ymj.1996.37.4.251 | - |
dc.contributor.localId | A02223 | - |
dc.contributor.localId | A02968 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 8942295 | - |
dc.contributor.alternativeName | Ahn, Duk Sun | - |
dc.contributor.affiliatedAuthor | 안덕선 | - |
dc.contributor.affiliatedAuthor | 이영호 | - |
dc.citation.volume | 37 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 251 | - |
dc.citation.endPage | 261 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.37(4) : 251-261, 1996-08 | - |
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