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Overexpression of c-ErbB-2 Protein in Gastric Cancer by Immunohistochemical Stain

Authors
 Lee H.R.  ;  Kim J.-H.  ;  Uhm H.D.  ;  Ahn J.B.  ;  Rha S.Y.  ;  Cho J.Y.  ;  Lee J.I.  ;  Lee K.H.  ;  Chung H.C.  ;  Roh J.K.  ;  Min J.S.  ;  Lee K.S.  ;  Shin D.H.  ;  Kim B.S.  ;  Kim B.S.  ;  Hong S.W.  ;  Choi J.-H. 
Citation
 ONCOLOGY, Vol.53(3) : 192-197, 1996-05 
Journal Title
ONCOLOGY
ISSN
 0030-2414 
Issue Date
1996-05
MeSH
Adult ; Aged ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Prognosis ; Receptor, ErbB-2 / analysis* ; Stomach Neoplasms / chemistry* ; Stomach Neoplasms / pathology ; Stomach Neoplasms / surgery ; Survival Analysis
Abstract
An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54% in the negative staining group to the c-ErbB-2 protein and 49% in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery.
Full Text
http://www.karger.com/Article/FullText/227559
DOI
10.1159/000227559
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hang(김주항)
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Cho, Jae Yong(조재용) ORCID logo https://orcid.org/0000-0002-0926-1819
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183095
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