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Adaptive Natural Killer Cells Facilitate Effector Functions of Daratumumab in Multiple Myeloma
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.contributor.author | 김진석 | - |
dc.contributor.author | 김창곤 | - |
dc.contributor.author | 민유홍 | - |
dc.contributor.author | 정준원 | - |
dc.contributor.author | 정해림 | - |
dc.contributor.author | 조현수 | - |
dc.date.accessioned | 2021-05-26T17:03:43Z | - |
dc.date.available | 2021-05-26T17:03:43Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182973 | - |
dc.description.abstract | Purpose: To investigate the different roles of heterogeneous natural killer (NK)-cell subpopulations in multiple myeloma and to identify NK-cell subsets that support the robust anti-myeloma activity of daratumumab via antibody-dependent cellular cytotoxicity (ADCC). Experimental design: We performed single-cell RNA sequencing of NK cells from patients with newly diagnosed multiple myeloma (NDMM) and delineated adaptive NK cells in their bone marrow (BM). We further characterized the distinct immunophenotypic features and functions of adaptive NK cells by multicolor flow cytometry in 157 patients with NDMM. Results: Adaptive NK cells exhibit a significantly lower level of CD38 expression compared with conventional NK cells, suggesting that they may evade daratumumab-induced fratricide. Moreover, adaptive NK cells exert robust daratumumab-mediated effector functions ex vivo, including cytokine production and degranulation, compared with conventional NK cells. The composition of adaptive NK cells in BM determines the daratumumab-mediated ex vivo functional activity of BM NK cells in patients with NDMM. Unlike conventional NK cells, sorted adaptive NK cells from the BM of patients with NDMM exert substantial cytotoxic activity against myeloma cells in the presence of daratumumab. Conclusions: Our findings indicate that adaptive NK cells are an important mediator of ADCC in multiple myeloma and support direct future efforts to better predict and improve the treatment outcome of daratumumab by selectively employing adaptive NK cells. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Association for Cancer Research | - |
dc.relation.isPartOf | CLINICAL CANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Adaptive Natural Killer Cells Facilitate Effector Functions of Daratumumab in Multiple Myeloma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Hyunsoo Cho | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.contributor.googleauthor | Hoyoung Lee | - |
dc.contributor.googleauthor | Chang Gon Kim | - |
dc.contributor.googleauthor | Haerim Chung | - |
dc.contributor.googleauthor | Yoon Seok Choi | - |
dc.contributor.googleauthor | Su-Hyung Park | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Yoo Hong Min | - |
dc.contributor.googleauthor | Eui-Cheol Shin | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.identifier.doi | 10.1158/1078-0432.CCR-20-3418 | - |
dc.contributor.localId | A05226 | - |
dc.contributor.localId | A01017 | - |
dc.contributor.localId | A05991 | - |
dc.contributor.localId | A01407 | - |
dc.contributor.localId | A02137 | - |
dc.contributor.localId | A03729 | - |
dc.contributor.localId | A04674 | - |
dc.contributor.localId | A03929 | - |
dc.relation.journalcode | J00564 | - |
dc.identifier.pmid | 33602683 | - |
dc.identifier.url | https://clincancerres.aacrjournals.org/content/27/10/2947.long | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.contributor.affiliatedAuthor | 김진석 | - |
dc.contributor.affiliatedAuthor | 김창곤 | - |
dc.contributor.affiliatedAuthor | 민유홍 | - |
dc.contributor.affiliatedAuthor | 정준원 | - |
dc.contributor.affiliatedAuthor | 정해림 | - |
dc.contributor.affiliatedAuthor | 조현수 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2947 | - |
dc.citation.endPage | 2958 | - |
dc.identifier.bibliographicCitation | CLINICAL CANCER RESEARCH, Vol.27(10) : 2947-2958, 2021-05 | - |
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