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Serum Dickkopf-1 in Combined with CA 19-9 as a Biomarker of Intrahepatic Cholangiocarcinoma
DC Field | Value | Language |
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dc.contributor.author | 김승업 | - |
dc.contributor.author | 김시영 | - |
dc.contributor.author | 방승민 | - |
dc.contributor.author | 이희승 | - |
dc.contributor.author | 정문재 | - |
dc.contributor.author | 최기홍 | - |
dc.contributor.author | 한대훈 | - |
dc.contributor.author | 황호경 | - |
dc.date.accessioned | 2021-05-26T17:01:46Z | - |
dc.date.available | 2021-05-26T17:01:46Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182957 | - |
dc.description.abstract | Dickkopf-related protein 1 (DKK-1) has a diagnostic and prognostic value in various malignant tumors. We investigated the diagnostic and prognostic performance of DKK-1 in combination with carbohydrate antigen 19-9 (CA 19-9) in cholangiocarcinoma (CCC) patients. Serum DKK-1 levels were measured using enzyme-linked immunosorbent assay. The receiver operating characteristic (ROC) curve, area under ROC (AUROC) analyses, Kaplan-Meier method, and Cox proportional hazard model were used to evaluate the diagnostic and prognostic performance of DKK-1 in combination with CA 19-9. We checked DKK-1 levels in 356 CCC patients and found that DKK-1 was significantly elevated only in 79 intrahepatic CCC (ICC) patients compared to controls (340.5 vs. 249.8 pg/mL, p = 0.002). The optimal cutoff level of DKK-1 used to identify ICC patients was 258.0 pg/mL (AUROC = 0.637, sensitivity = 59.5%, specificity = 56.9%, positive predictive value (PPV) = 40.5%, negative predictive value (NPV) = 74.0%, positive likelihood ratio (LR) = 1.38, and negative LR = 0.71). Using this cutoff, 47 (59.5%) patients were correctly diagnosed with ICC. DKK-1 in combination with CA 19-9 showed a better diagnostic performance (AUROC = 0.793, sensitivity = 74.7%, specificity = 56.3%, PPV = 45.7, NPV = 81.8, positive LR = 1.71, and negative LR = 0.45) than CA 19-9 alone. The low DKK-1 and CA 19-9 expression group had a significantly longer overall survival (OS) than the high expression group (p = 0.006). The higher level of DKK-1 and CA 19-9 was independently associated with shorter OS (hazard ratio = 3.077, 95% confidence interval 1.389-6.819, p = 0.006). The diagnostic and prognostic performance of DKK-1 in combination with CA 19-9 might be better than those of CA 19-9 alone in ICC patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Serum Dickkopf-1 in Combined with CA 19-9 as a Biomarker of Intrahepatic Cholangiocarcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Si-Young Kim | - |
dc.contributor.googleauthor | Hee-Seung Lee | - |
dc.contributor.googleauthor | Seung-Min Bang | - |
dc.contributor.googleauthor | Dai-Hoon Han | - |
dc.contributor.googleauthor | Ho-Kyoung Hwang | - |
dc.contributor.googleauthor | Gi-Hong Choi | - |
dc.contributor.googleauthor | Moon-Jae Chung | - |
dc.contributor.googleauthor | Seung-Up Kim | - |
dc.identifier.doi | 10.3390/cancers13081828 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A06071 | - |
dc.contributor.localId | A01786 | - |
dc.contributor.localId | A03349 | - |
dc.contributor.localId | A03602 | - |
dc.contributor.localId | A04046 | - |
dc.contributor.localId | A04273 | - |
dc.contributor.localId | A04497 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 33921232 | - |
dc.subject.keyword | carbohydrate antigen 19-9 | - |
dc.subject.keyword | diagnosis | - |
dc.subject.keyword | dickkopf-related protein 1 | - |
dc.subject.keyword | intrahepatic cholangiocarcinoma | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | 김승업 | - |
dc.contributor.affiliatedAuthor | 김시영 | - |
dc.contributor.affiliatedAuthor | 방승민 | - |
dc.contributor.affiliatedAuthor | 이희승 | - |
dc.contributor.affiliatedAuthor | 정문재 | - |
dc.contributor.affiliatedAuthor | 최기홍 | - |
dc.contributor.affiliatedAuthor | 한대훈 | - |
dc.contributor.affiliatedAuthor | 황호경 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1828 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.13(8) : 1828, 2021-04 | - |
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