0 0

Cited 0 times in

IL-1β induces expression of proinflammatory cytokines and migration of human colon cancer cells through upregulation of SIRT1

Authors
 Jaekyung Jung  ;  Yeon-Hwa Lee  ;  Xizhu Fang  ;  Su-Jung Kim  ;  Seong Hoon Kim  ;  Do-Hee Kim  ;  Na-Young Song  ;  Hye-Kyung Na  ;  Jeong-Heum Baek  ;  Young-Joon Surh 
Citation
 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol.703 : 108847, 2021-05 
Journal Title
 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 
ISSN
 0003-9861 
Issue Date
2021-05
Keywords
Human colon cancer HCT-116 cells ; IL-1β ; Proinflammatory cytokines ; SIRT1 ; c-Jun
Abstract
SIRT1 is a mammalian NAD+-dependent deacetylase, which is known to be involved in various physiological events, such as adaptive response to environmental stresses including caloric restriction, as well as in aging and cellular senescence. However, recent studies have revealed overexpression of SIRT1 in many different types of human malignancies, particularly colon cancer. Interleukin-1β (IL-1β) is a proinflammatory cytokine that plays a major role in invasiveness, stemness and progression of colon cancer. However, the interaction between IL-1β and SIRT1 in the tumor development and progression remains elusive. In this study, we found that IL-1β induces SIRT1 protein expression in human colon cancer HCT-116 cells. IL-1β-induced SIRT1 upregulation led to enhanced expression of mRNA transcripts of pro-inflammatory cytokines, IL-6 and IL-8 as well as that of IL-1β. Knockdown of SIRT1 prevented IL-1β-induced phosphorylation and nuclear accumulation of c-Jun. Furthermore, pharmacologic inhibition of SIRT1 abrogated clonogenicity and migrative capability of human colon cancer cells stimulated with IL-1β. In summary, IL-1β-induced SIRT1 upregulation stimulates production of proinflammatory cytokines via a nuclear accumulation of c-Jun, leadng to colon cancer growth and progression.
Full Text
https://www.sciencedirect.com/science/article/pii/S0003986121000977
DOI
10.1016/j.abb.2021.108847
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Song, Na-Young(송나영) ORCID logo https://orcid.org/0000-0001-8658-7049
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182939
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links