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Clinical Implications of Geometric and Dosimetric Uncertainties of Inter- and Intra-Fractional Movement during Volumetric Modulated Arc Therapy for Breast Cancer Patients
DC Field | Value | Language |
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dc.contributor.author | 이익재 | - |
dc.contributor.author | 이호 | - |
dc.contributor.author | 조연아 | - |
dc.date.accessioned | 2021-05-26T16:59:37Z | - |
dc.date.available | 2021-05-26T16:59:37Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182936 | - |
dc.description.abstract | With the introduction of modern sophisticated radiotherapy (RT) techniques, the significance of accuracy has increased considerably. This study evaluated the necessity of pre-treatment and intra-fractional cone-beam computed tomography (CBCT) by analyzing inter- and intra-fractional CBCT images of breast cancer patients receiving RT. From 57 patients, 1206 pre-treatment CBCT and 1067 intra-fractional CBCT images were collected. Geometric movements of patients were measured quantitively in both inter- and intra-fractional CBCT, and changes in dosimetric parameters were evaluated in selected patients with extreme intra-fractional movement. For right-sided breast cancer patients, left-sided breast cancer patients treated using deep-inspiration breath hold (DIBH), and left-sided breast cancer patients treated using continuous positive airway pressure (CPAP), median inter-fractional deviations were 0.53 (range 0.06-2.98) cm, 0.66 (range 0.08-4.41) cm, and 0.69 (range 0.04-3.80) cm, and median intra-fractional deviations were 0.14 (range 0.00-0.62) cm, 0.23 (range 0.02-0.96) cm, and 0.24 (0.00-1.15) cm, respectively. Modified plans reflecting large changes in intra-fractional position in 10 selected cases revealed insufficient target coverage in seven cases and more than 20-fold increase in the volume of heart receiving at least 25 Gy in two cases. Intra-fractional verification, as well as pre-treatment verification, might be considered in patients using DIBH or CPAP. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Clinical Implications of Geometric and Dosimetric Uncertainties of Inter- and Intra-Fractional Movement during Volumetric Modulated Arc Therapy for Breast Cancer Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Jason Joon Bock Lee | - |
dc.contributor.googleauthor | Ik Jae Lee | - |
dc.contributor.googleauthor | Yeonho Choi | - |
dc.contributor.googleauthor | Mi Jin Jeon | - |
dc.contributor.googleauthor | Il Hun Jung | - |
dc.contributor.googleauthor | Ho Lee | - |
dc.identifier.doi | 10.3390/cancers13071651 | - |
dc.contributor.localId | A03055 | - |
dc.contributor.localId | A03323 | - |
dc.contributor.localId | A04680 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 33916047 | - |
dc.subject.keyword | breast cancer | - |
dc.subject.keyword | cone-beam computed tomography | - |
dc.subject.keyword | image-guided radiotherapy | - |
dc.subject.keyword | intrafraction motion | - |
dc.subject.keyword | volumetric modulated arc therapy | - |
dc.contributor.alternativeName | Lee, Ik Jae | - |
dc.contributor.affiliatedAuthor | 이익재 | - |
dc.contributor.affiliatedAuthor | 이호 | - |
dc.contributor.affiliatedAuthor | 조연아 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1651 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.13(7) : 1651, 2021-04 | - |
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