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Male Sex Is a Significant Predictor of All-cause Mortality in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitis

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dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author안성수-
dc.contributor.author이상원-
dc.contributor.author이은주-
dc.contributor.author표정윤-
dc.date.accessioned2021-05-26T16:59:14Z-
dc.date.available2021-05-26T16:59:14Z-
dc.date.issued2021-05-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182934-
dc.description.abstractBackground: We investigated and compared the initial clinical features at diagnosis and the poor outcomes during follow-up in Korean patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) based on sex. Methods: The medical records of 223 immunosuppressive drug-naïve patients with AAV were reviewed. Age, body mass index (BMI), smoking history, AAV subtypes, ANCA positivity, clinical manifestations, Birmingham vasculitis activity score (BVAS), five-factor score (FFS), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) at diagnosis were collected. All-cause mortality, end-stage renal disease (ESRD), cerebrovascular accident (CVA) and cardiovascular disease (CVD) were assessed as the poor outcomes of AAV during follow-up. Results: The median age was 59.0 years and 74 of 223 AAV patients (33.2%) were men. Among variables at diagnosis, male patients exhibited higher BMI than female. However, there were no differences in other demographic data, AAV subtypes, ANCA positivity, BVAS, FFS, ESR and CRP between the two groups. Male patients received cyclophosphamide more frequently, but there were no significant differences in the frequencies of the poor outcomes of AAV between the two groups. Male patients exhibited a significantly lower cumulative patients' survival rate than female patients during the follow-up period based on all-cause mortality (P = 0.037). In the multivariable analysis, both male sex (hazard ratio [HR], 2.378) and FFS (HR, 1.693) at diagnosis were significantly and independently associated with all-cause mortality during follow-up. Conclusion: Male sex is a significant and independent predictor of all-cause mortality in AAV patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisher대한의학회(The Korean Academy of Medical Sciences)-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMale Sex Is a Significant Predictor of All-cause Mortality in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHyeok Chan Kwon-
dc.contributor.googleauthorJung Yoon Pyo-
dc.contributor.googleauthorLucy Eunju Lee-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong Beom Park-
dc.contributor.googleauthorSang Won Lee-
dc.identifier.doi10.3346/jkms.2021.36.e120-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA02233-
dc.contributor.localIdA02824-
dc.contributor.localIdA05935-
dc.contributor.localIdA04244-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid33975396-
dc.subject.keywordAntineutrophil Cytoplasmic Antibody Vasculitis-
dc.subject.keywordClinical Features-
dc.subject.keywordDifference-
dc.subject.keywordPrognosis-
dc.subject.keywordSex-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.affiliatedAuthor박용범-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor안성수-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor이은주-
dc.contributor.affiliatedAuthor표정윤-
dc.citation.volume36-
dc.citation.number18-
dc.citation.startPagee120-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.36(18) : e120, 2021-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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