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Performance Evaluation of the Newly Developed In Vitro Rapid Diagnostic Test for Detecting OXA-48-Like, KPC-, NDM-, VIM- and IMP-Type Carbapenemases: The RESIST-5 O.K.N.V.I. Multiplex Lateral Flow Assay
DC Field | Value | Language |
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dc.contributor.author | 김도균 | - |
dc.date.accessioned | 2021-05-26T16:59:11Z | - |
dc.date.available | 2021-05-26T16:59:11Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182933 | - |
dc.description.abstract | The objective of this study was to evaluate the performance of the RESIST-5 O.K.N.V.I. assay for identifying these five common domestic carbapenemases among a large number of clinical isolates in South Korea. A total of 268 non-duplicated clinical isolates of gram-negative bacilli were included in this study as follows: 258 carbapenemase-producing (CP) strains (OXA-48-like, KPC, NDM, VIM, IMP, GES, OXA-23 and two or more carbapenemase producers) and 10 non-CP carbapenem-resistant Enterobacterales (non-CP CREs). Overall sensitivity and specificity were 98.4% and 100%, respectively. In addition, all non-targeted carbapenemase producers including GES and OXA-23 producers and non-CP CREs were correctly identified as negative results. There were only four discrepant cases in which three VIM carbapenemase producers and one NDM carbapenemase producer were not detected. The RESIST-5 O.K.N.V.I. assay as an in vitro diagnostic test for detecting five common carbapenemases provided rapid and accurate results in a short time, indicating that this method could provide an innovative solution for early detection, resulting in appropriate antimicrobial treatment in the clinical field. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.relation.isPartOf | ANTIBIOTICS-BASEL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Performance Evaluation of the Newly Developed In Vitro Rapid Diagnostic Test for Detecting OXA-48-Like, KPC-, NDM-, VIM- and IMP-Type Carbapenemases: The RESIST-5 O.K.N.V.I. Multiplex Lateral Flow Assay | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Junsung Hong | - |
dc.contributor.googleauthor | Dayoung Kang | - |
dc.contributor.googleauthor | Dokyun Kim | - |
dc.identifier.doi | 10.3390/antibiotics10040460 | - |
dc.contributor.localId | A04891 | - |
dc.relation.journalcode | J03862 | - |
dc.identifier.eissn | 2079-6382 | - |
dc.identifier.pmid | 33921669 | - |
dc.subject.keyword | IMP | - |
dc.subject.keyword | KPC | - |
dc.subject.keyword | NDM | - |
dc.subject.keyword | OXA-48-like | - |
dc.subject.keyword | RESIST-5 O.K.N.V.I. assay | - |
dc.subject.keyword | VIM | - |
dc.subject.keyword | carbapenemase | - |
dc.subject.keyword | carbapenemase-producing organisms | - |
dc.subject.keyword | evaluation | - |
dc.contributor.alternativeName | Kim, Dokyun | - |
dc.contributor.affiliatedAuthor | 김도균 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 460 | - |
dc.identifier.bibliographicCitation | ANTIBIOTICS-BASEL, Vol.10(4) : 460, 2021-04 | - |
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