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Comparison of Oncologic Outcomes between Transduodenal Ampullectomy and Pancreatoduodenectomy in Ampulla of Vater Cancer: Korean Multicenter Study
DC Field | Value | Language |
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dc.contributor.author | 박준성 | - |
dc.contributor.author | 홍승수 | - |
dc.contributor.author | 황호경 | - |
dc.date.accessioned | 2021-05-26T16:58:02Z | - |
dc.date.available | 2021-05-26T16:58:02Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182921 | - |
dc.description.abstract | This study used multicenter data to compare the oncological safety of transduodenal ampullectomy (TDA) with that of pylorus-preserving pancreatoduodenectomy (PPPD) in early ampulla of Vater (AoV) cancer. Data for patients who underwent surgical resection for AoV cancer (pTis-T2 stage) from January 2000 to September 2019 were collected from 15 institutions. The clinicopathologic characteristics and survival outcomes were compared between the PPPD and TDA groups. A total of 486 patients were enrolled (PPPD, 418; TDA, 68). The oncologic behavior in the PPPD group was more aggressive than that in the TDA group at all T stages: larger tumor size (p = 0.034), advanced T stage (p < 0.001), aggressive cell differentiation (p < 0.001), and more lymphovascular invasion (p = 0.002). Five-year disease-free survival (DFS) and overall survival (OS) did not differ between the two groups when considering all T stages or only the Tis+T1 group. Among T1 patients, PPPD produced significantly better DFS (PPPD vs. TDA, 84.8% vs. 66.6%, p = 0.040) and superior OS (PPPD vs. TDA, 89.1% vs. 68.0%, p = 0.056) than TDA. Lymph node dissection (LND) in the TDA group did not affect DFS or OS (TDA + LND vs. TDA-only, DFS, p = 0.784; OS, p = 0.870). In conclusion, PPPD should be the standard procedure for early AoV cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Comparison of Oncologic Outcomes between Transduodenal Ampullectomy and Pancreatoduodenectomy in Ampulla of Vater Cancer: Korean Multicenter Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Seung-Soo Hong | - |
dc.contributor.googleauthor | Sung-Sik Han | - |
dc.contributor.googleauthor | Wooil Kwon | - |
dc.contributor.googleauthor | Jin-Young Jang | - |
dc.contributor.googleauthor | Hee-Joon Kim | - |
dc.contributor.googleauthor | Chol-Kyoon Cho | - |
dc.contributor.googleauthor | Keun-Soo Ahn | - |
dc.contributor.googleauthor | Jae-Do Yang | - |
dc.contributor.googleauthor | Youngmok Park | - |
dc.contributor.googleauthor | Seog-Ki Min | - |
dc.contributor.googleauthor | Ju-Ik Moon | - |
dc.contributor.googleauthor | Young-Hoon Roh | - |
dc.contributor.googleauthor | Seung-Eun Lee | - |
dc.contributor.googleauthor | Joon-Seong Park | - |
dc.contributor.googleauthor | Sang-Geol Kim | - |
dc.contributor.googleauthor | Chi-Young Jeong | - |
dc.contributor.googleauthor | Jin-Seok Heo | - |
dc.contributor.googleauthor | Ho-Kyoung Hwang | - |
dc.identifier.doi | 10.3390/cancers13092038 | - |
dc.contributor.localId | A01672 | - |
dc.contributor.localId | A05072 | - |
dc.contributor.localId | A04497 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 33922504 | - |
dc.subject.keyword | ampulla of Vater cancer | - |
dc.subject.keyword | pancreaticoduodenectomy | - |
dc.subject.keyword | transduodenal ampullectomy | - |
dc.contributor.alternativeName | Park, Joon Seong | - |
dc.contributor.affiliatedAuthor | 박준성 | - |
dc.contributor.affiliatedAuthor | 홍승수 | - |
dc.contributor.affiliatedAuthor | 황호경 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2038 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.13(9) : 2038, 2021-04 | - |
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