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Initial topical monotherapy may increase the risk of recurrence in patients with extramammary Paget's disease
DC Field | Value | Language |
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dc.contributor.author | 노미령 | - |
dc.contributor.author | 오병호 | - |
dc.contributor.author | 오영주 | - |
dc.contributor.author | 정기양 | - |
dc.date.accessioned | 2021-05-26T16:53:21Z | - |
dc.date.available | 2021-05-26T16:53:21Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 0385-2407 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182882 | - |
dc.description.abstract | Although topical therapies are used to treat extramammary Paget's disease (EMPD), reliable treatment outcomes and the effects of these therapies on subsequent surgical treatments are unclear. To assess the clinical outcomes of topical treatment of EMPD and establish the treatment guidelines the medical records of 166 patients diagnosed with EMPD were retrospectively reviewed. The recurrence rate was evaluated according to the previous use of topical agents. Thirty-four patients (34/166, 20.5%) were initially treated with topical agents such as imiquimod, 5-fluorouracil, and ingenol mebutate. Three patients (3/34, 8.8%) showed clinical response, while 31 patients required subsequent therapy owing to treatment failure. Analysis of the prognostic factors of recurrence in 166 patients revealed that initial topical treatment increased the hazard ratio (HR) in both univariate and multiple Cox proportional hazards models (HR = 3.770, 95% confidence interval [CI] = 1.768-8.037, P = 0.001, and adjusted HR = 3.628, 95% CI = 1.558-8.450, P = 0.003). Patients treated with topical agents showed significantly poorer 3-year recurrence-free survival than the nontreated group (66.3% vs 88.6%, P < 0.001). Topical treatment may be deleterious for some EMPD patients, thus increasing the recurrence risk. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | JOURNAL OF DERMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Fluorouracil | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Imiquimod | - |
dc.subject.MESH | Neoplasm Recurrence, Local / drug therapy | - |
dc.subject.MESH | Paget Disease, Extramammary* / drug therapy | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Initial topical monotherapy may increase the risk of recurrence in patients with extramammary Paget's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Sooyie Choi | - |
dc.contributor.googleauthor | Yeongjoo Oh | - |
dc.contributor.googleauthor | Mi Ryung Roh | - |
dc.contributor.googleauthor | Kee Yang Chung | - |
dc.contributor.googleauthor | Byung Ho Oh | - |
dc.identifier.doi | 10.1111/1346-8138.15794 | - |
dc.contributor.localId | A01278 | - |
dc.contributor.localId | A02367 | - |
dc.contributor.localId | A05152 | - |
dc.contributor.localId | A03582 | - |
dc.relation.journalcode | J01372 | - |
dc.identifier.eissn | 1346-8138 | - |
dc.identifier.pmid | 33666282 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/1346-8138.15794 | - |
dc.subject.keyword | Mohs micrographic surgery | - |
dc.subject.keyword | extramammary Paget's disease | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | recurrence | - |
dc.subject.keyword | topical | - |
dc.contributor.alternativeName | Roh, Mi Ryung | - |
dc.contributor.affiliatedAuthor | 노미령 | - |
dc.contributor.affiliatedAuthor | 오병호 | - |
dc.contributor.affiliatedAuthor | 오영주 | - |
dc.contributor.affiliatedAuthor | 정기양 | - |
dc.citation.volume | 48 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 585 | - |
dc.citation.endPage | 591 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DERMATOLOGY, Vol.48(5) : 585-591, 2021-05 | - |
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