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Association Between Serum Alarmin Levels and Disease-specific Indices in Patients With Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 송정식 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 조윤희 | - |
dc.date.accessioned | 2021-05-26T16:53:14Z | - |
dc.date.available | 2021-05-26T16:53:14Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 0258-851X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182881 | - |
dc.description.abstract | Background/aim: We evaluated the relationship between serum alarmin levels and disease-specific indices in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Patients and methods: Sera and data from 79 patients were utilized. For AAV-specific indices, Birmingham vasculitis activity score (BVAS), five-factor score (FFS), and vasculitis damage index (VDI) were collected and serum levels of four alarmins (hepatoma-derived growth factor, high mobility group box protein 1, S100A9, and S100A12) were measured using enzyme-linked immunosorbent assay. Associations between alarmin levels, AAV-specific indices, and inflammatory laboratory markers were assessed. Results: S100A9 levels were significantly correlated with C-reactive protein levels (r=0.316, p=0.005) and S100A12 levels correlated with VDI (r=0.232, p=0.040), which was consistent in a subgroup of patients with myeloperoxidase (perinuclear)-ANCA positivity. No other associations were found between alarmin levels and BVAS, FFS, and VDI. Conclusion: The serum S100A12 level was associated with organ damage in AAV, especially in myeloperoxidase (perinuclear)-ANCA-positive patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Delinassios | - |
dc.relation.isPartOf | IN VIVO | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association Between Serum Alarmin Levels and Disease-specific Indices in Patients With Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sung Soo Ahn | - |
dc.contributor.googleauthor | Taejun Yoon | - |
dc.contributor.googleauthor | Jason Jungsik Song | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.identifier.doi | 10.21873/invivo.12435 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02057 | - |
dc.contributor.localId | A02233 | - |
dc.contributor.localId | A02824 | - |
dc.relation.journalcode | J01043 | - |
dc.identifier.eissn | 1791-7549 | - |
dc.identifier.pmid | 33910860 | - |
dc.identifier.url | https://iv.iiarjournals.org/content/35/3/1761.long | - |
dc.subject.keyword | Anti-neutrophil cytoplasmic antibody-associated vasculitis | - |
dc.subject.keyword | S100A12 | - |
dc.subject.keyword | alarmins | - |
dc.subject.keyword | biomarker | - |
dc.subject.keyword | damage | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | 박용범 | - |
dc.contributor.affiliatedAuthor | 송정식 | - |
dc.contributor.affiliatedAuthor | 안성수 | - |
dc.contributor.affiliatedAuthor | 이상원 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1761 | - |
dc.citation.endPage | 1768 | - |
dc.identifier.bibliographicCitation | IN VIVO, Vol.35(3) : 1761-1768, 2021-05 | - |
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