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Efficacy of low dose and short duration defibrotide prophylaxis for hepatic veno-occlusive disease after autologous haematopoietic stem cell transplantation
DC Field | Value | Language |
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dc.contributor.author | 안원기 | - |
dc.contributor.author | 유철주 | - |
dc.contributor.author | 한승민 | - |
dc.contributor.author | 한정우 | - |
dc.date.accessioned | 2021-05-26T16:50:13Z | - |
dc.date.available | 2021-05-26T16:50:13Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 0268-3369 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182854 | - |
dc.description.abstract | Hepatic veno-occlusive disease (VOD) is a serious systemic endothelial complication after stem cell transplantation. Defibrotide is under investigation as a prophylactic agent for VOD; however, high costs limit its utility. We evaluated the prophylactic efficacy of a low-dose defibrotide regimen for VOD. We retrospectively enrolled 147 paediatric patients who underwent autologous haematopoietic stem cell transplantation (HSCT; 69 with defibrotide prophylaxis and 78 historical controls) at the Yonsei Cancer Center in Seoul, Korea, between March 2013 and Feb 2020. Low-dose defibrotide (12.5 mg/kg/day) was administered from D-3 to D+10 after HSCT. The most common diagnosis in the cohort was brain tumour (N = 86). VOD developed in 10 (12.8%) and 3 (4.3%) patients in the control and prophylaxis groups, respectively (P = 0.071). In the second HSCT group, VOD incidence was significantly lower in the prophylaxis group [2.9% (1/35)] than in the control group (28.6%, 6/21, P = 0.005). VOD severity was significantly higher in the control group than in the prophylaxis group (P = 0.006). Three VOD-related mortalities occurred in the control group, whereas no VOD-related mortality occurred in the prophylaxis group. In conclusion, low-dose defibrotide prophylaxis is a promising and economical strategy for preventing VOD, especially in second-round HSCT. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | BONE MARROW TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Efficacy of low dose and short duration defibrotide prophylaxis for hepatic veno-occlusive disease after autologous haematopoietic stem cell transplantation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | ;Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Yun Young Roh | - |
dc.contributor.googleauthor | Seung Min Hahn | - |
dc.contributor.googleauthor | Hyo Sun Kim | - |
dc.contributor.googleauthor | Won Kee Ahn | - |
dc.contributor.googleauthor | Jung Hwa Han | - |
dc.contributor.googleauthor | Seungyeon Kwon | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.contributor.googleauthor | Jung Woo Han | - |
dc.identifier.doi | 10.1038/s41409-020-01036-5 | - |
dc.contributor.localId | A05357 | - |
dc.contributor.localId | A02524 | - |
dc.contributor.localId | A04299 | - |
dc.contributor.localId | A04325 | - |
dc.relation.journalcode | J00383 | - |
dc.identifier.eissn | 1476-5365 | - |
dc.identifier.pmid | 32839533 | - |
dc.identifier.url | https://www.nature.com/articles/s41409-020-01036-5 | - |
dc.contributor.alternativeName | Ahn, Won Kee | - |
dc.contributor.affiliatedAuthor | 안원기 | - |
dc.contributor.affiliatedAuthor | 유철주 | - |
dc.contributor.affiliatedAuthor | 한승민 | - |
dc.contributor.affiliatedAuthor | 한정우 | - |
dc.citation.volume | 56 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 411 | - |
dc.citation.endPage | 418 | - |
dc.identifier.bibliographicCitation | BONE MARROW TRANSPLANTATION, Vol.56(2) : 411-418, 2021-02 | - |
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