Cited 0 times in
Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System in Children under the Age of 3 Years
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유철주 | - |
dc.contributor.author | 한승민 | - |
dc.contributor.author | 한정우 | - |
dc.date.accessioned | 2021-05-26T16:50:07Z | - |
dc.date.available | 2021-05-26T16:50:07Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182853 | - |
dc.description.abstract | Purpose: Atypical teratoid/rhabdoid tumor (ATRT) is a highly aggressive malignancy with peak incidence in children aged less than 3 years. Standard treatment for central nervous system ATRT in children under the age of 3 years have not been established yet. The objective of this study was to analyze characteristics and clinical outcomes of ATRT in children aged less than 3 years. Materials and methods: A search of medical records from seven centers was performed between January 2005 and December 2016. Results: Forty-three patients were enrolled. With a median follow-up of 90 months, 27 patients (64.3%) showed at least one episode of disease progression (PD). The first date of PD was at 160 days after diagnosis. The 1- and 3-year progression-free survivals (PFS) were 51.2% and 28.5%, respectively. The 1- and 3-year overall survivals were 61.9% and 38.1%, respectively. The 3-year PFS was improved from 0% in pre-2011 to 47.4% in post-2011. Excluding one patient who did not receive any further therapy after surgery, 27 patients died due to PD (n=21), treatment-related toxicity (n=5), or unknown cause (n=1). In univariate analysis, factors associated with higher 3-year PFS were no metastases, diagnosis after 2011, early adjuvant radiotherapy, and high-dose chemotherapy (HDCT). In multivariate analysis, the use of HDCT and adjuvant radiotherapy remained significant prognostic factors for PFS (both p < 0.01). Conclusion: Aggressive therapy including early adjuvant radiotherapy and HDCT could be considered to improve outcomes of ATRT in children under the age of 3 years. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System in Children under the Age of 3 Years | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | ;Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Meerim Park | - |
dc.contributor.googleauthor | Jung Woo Han | - |
dc.contributor.googleauthor | Seung Min Hahn | - |
dc.contributor.googleauthor | Jun Ah Lee | - |
dc.contributor.googleauthor | Joo-Young Kim | - |
dc.contributor.googleauthor | Sang Hoon Shin | - |
dc.contributor.googleauthor | Dong-Seok Kim | - |
dc.contributor.googleauthor | Hong In Yoon | - |
dc.contributor.googleauthor | Kyung Taek Hong | - |
dc.contributor.googleauthor | Jung Yoon Choi | - |
dc.contributor.googleauthor | Hyoung Jin Kang | - |
dc.contributor.googleauthor | Hee Young Shin | - |
dc.contributor.googleauthor | Ji Hoon Phi | - |
dc.contributor.googleauthor | Seung-Ki Kim | - |
dc.contributor.googleauthor | Ji Won Lee | - |
dc.contributor.googleauthor | Keon Hee Yoo | - |
dc.contributor.googleauthor | Ki Woong Sung | - |
dc.contributor.googleauthor | Hong Hoe Koo | - |
dc.contributor.googleauthor | Do Hoon Lim | - |
dc.contributor.googleauthor | Hyung Jin Shin | - |
dc.contributor.googleauthor | Hyery Kim | - |
dc.contributor.googleauthor | Kyung-Nam Koh | - |
dc.contributor.googleauthor | Ho Joon Im | - |
dc.contributor.googleauthor | Seung Do Ahn | - |
dc.contributor.googleauthor | Young-Shin Ra | - |
dc.contributor.googleauthor | Hee-Jo Baek | - |
dc.contributor.googleauthor | Hoon Kook | - |
dc.contributor.googleauthor | Tae-Young Jung | - |
dc.contributor.googleauthor | Hyoung Soo Choi | - |
dc.contributor.googleauthor | Chae-Yong Kim | - |
dc.contributor.googleauthor | Hyeon Jin Park | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.identifier.doi | 10.4143/crt.2020.756 | - |
dc.contributor.localId | A02524 | - |
dc.contributor.localId | A04299 | - |
dc.contributor.localId | A04325 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 33138347 | - |
dc.subject.keyword | ATRT | - |
dc.subject.keyword | Children | - |
dc.subject.keyword | High-dose chemotherapy | - |
dc.subject.keyword | Radiotherapy | - |
dc.contributor.alternativeName | Lyu, Chuhl Joo | - |
dc.contributor.affiliatedAuthor | 유철주 | - |
dc.contributor.affiliatedAuthor | 한승민 | - |
dc.contributor.affiliatedAuthor | 한정우 | - |
dc.citation.volume | 53 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 378 | - |
dc.citation.endPage | 388 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.53(2) : 378-388, 2021-04 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.