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Fibrinogen to albumin ratio reflects the activity of antineutrophil cytoplasmic antibody-associated vasculitis

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dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author안성수-
dc.contributor.author이상원-
dc.contributor.author이은주-
dc.contributor.author표정윤-
dc.date.accessioned2021-05-26T16:49:41Z-
dc.date.available2021-05-26T16:49:41Z-
dc.date.issued2021-04-
dc.identifier.issn0887-8013-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182850-
dc.description.abstractBackground: We investigated whether fibrinogen to albumin ratio (FAR) at diagnosis could reflect the cross-sectional activity and predict poor outcomes in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Methods: This cross-sectional study included 54 immunosuppressant drug-naïve patients with AAV who had the results of plasma fibrinogen and serum albumin at diagnosis. Clinical and laboratory data at diagnosis were collected, and all-cause mortality, cerebrovascular accident, cardiovascular disease, end-stage renal disease occurrences were assessed as poor outcomes. FAR was calculated by the following equation: FAR = plasma fibrinogen (g/dl)/serum albumin (g/dl). Results: The median age was 65.5 years, and 59.3% of patients were men (33 MPA, 13 GPA and 8 EGPA). FAR was significantly correlated with Birmingham vasculitis activity score (BVAS; r = 0.271), erythrocyte sedimentation rate (ESR; r = 0.668) and C-reactive protein (CRP; r = 0.638). High BVAS was defined as BVAS ≥16, and the cut-off of FAR at diagnosis was set as 0.118. AAV patients with FAR at diagnosis ≥0.118 had a significantly higher risk for the cross-sectional high BVAS than those without (RR 3.361). In the univariable linear regression analysis, CRP (β = 0.383) and FAR (β = 0.297) were significantly correlated with BVAS at diagnosis. However, in the multivariable analysis, none of them was correlated with the cross-sectional BVAS. FAR at diagnosis could not predict poor outcomes during follow-up in AAV patients. Conclusions: Fibrinogen to albumin ratio at diagnosis could reflect the cross-sectional BVAS but could not predict poor outcomes in patients with AAV.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWiley-Liss, Inc.-
dc.relation.isPartOfJOURNAL OF CLINICAL LABORATORY ANALYSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleFibrinogen to albumin ratio reflects the activity of antineutrophil cytoplasmic antibody-associated vasculitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorLucy Eunju Lee-
dc.contributor.googleauthorJung Yoon Pyo-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorSang-Won Lee-
dc.identifier.doi10.1002/jcla.23731-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA02233-
dc.contributor.localIdA02824-
dc.contributor.localIdA05935-
dc.contributor.localIdA04244-
dc.relation.journalcodeJ01323-
dc.identifier.eissn1098-2825-
dc.identifier.pmid33591581-
dc.subject.keywordantineutrophil cytoplasmic antibody-
dc.subject.keywordbirmingham vasculitis activity score-
dc.subject.keywordfibrinogen to albumin ratio-
dc.subject.keywordvasculitis-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.affiliatedAuthor박용범-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor안성수-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor이은주-
dc.contributor.affiliatedAuthor표정윤-
dc.citation.volume35-
dc.citation.number4-
dc.citation.startPagee23731-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL LABORATORY ANALYSIS, Vol.35(4) : e23731, 2021-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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