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A neural mechanism of the relationship between impulsivity and emotion dysregulation in patients with Internet gaming disorder

Authors
 Yu-Bin Shin  ;  Hyunji Kim  ;  Soo-Jeong Kim  ;  Jae-Jin Kim 
Citation
 ADDICTION BIOLOGY, Vol.26(3) : e12916, 2021-05 
Journal Title
 ADDICTION BIOLOGY 
ISSN
 1355-6215 
Issue Date
2021-05
Keywords
Internet gaming disorder ; emotion regulation ; functional magnetic resonance imaging ; impulsivity
Abstract
Impulsivity and emotion dysregulation have been known to be risk factors for Internet gaming disorder (IGD), but their underlying neural mechanisms are not yet fully understood. Given that the prefrontal cortex has a key role in higher order cognition and addiction, the present study aimed to investigate emotional influences on response inhibition in situations with different cognitive demands. A total of 41 young male adults (20 with and 21 without IGD) were scanned while performing two versions of an emotional go/no-go task with demands on low and high working memory load. Patients with IGD showed a failure in response inhibition and increased activation of widespread brain regions, including prefrontal, motor-sensory, parietal, occipital, insula, and striatal regions across tasks. Among these regions, involvement of the dorsolateral prefrontal cortex and ventral striatum was observed only during the task with high demands on working memory. Moreover, it was also only during the high-load task that interaction between response inhibition and emotional states was observed in the dorsomedial prefrontal cortex, with observations revealing that its alteration in patients with IGD was associated with number of hours spent on Internet gaming. Our findings highlight a failure of response inhibition and dysfunction within the inhibitory control network. The special significance of our study is that dysfunctional dorsomedial prefrontal cortex may mediate abnormal emotional influences on response inhibition in patients with IGD.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/adb.12916
DOI
10.1111/adb.12916
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo-Jeong(김수정) ORCID logo https://orcid.org/0000-0001-9065-7492
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182843
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