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The clinical and economic burden of community-onset complicated skin and skin structure infections in Korea

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dc.contributor.author송영구-
dc.contributor.author한상훈-
dc.date.accessioned2021-05-21T17:11:43Z-
dc.date.available2021-05-21T17:11:43Z-
dc.date.issued2020-11-
dc.identifier.issn1226-3303-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182759-
dc.description.abstractBackground/aims: To investigate epidemiologic characteristics, clinical and economic burdens, and factors associated with mortality in complicated skin and skin structure infection (cSSSI) patients in Korea. Methods: A retrospective, observational, nationwide study was conducted between April to July 2012 at 14 tertiary-hospitals in Korea. Eligible patients were hospitalized adults with community acquired cSSSI, who underwent surgical intervention and completed treatment between November 2009 and October 2011. Data on demography, clinical characteristics, outcomes and medical resource utilization were collected through medical record review. Direct medical costs were calculated by multiplying quantities of resources utilized by each unit price in Korea. Results: Of 473 patients enrolled, 449 patients (except 24 patients with no record on surgical intervention) were eligible for analysis. Microbiological testing was performed on 66.1% of patients and 8.2% had multiple pathogens. Among culture confirmed pathogens (n = 297 patients, 340 episodes), 76.2% were gram-positive (Staphylococcus aureus; 41.2%) and 23.8% were gram-negative. The median duration of hospital stay was 16 days. Among treated patients, 3.3% experienced recurrence and 4.2% died in-hospital. The mean direct medical costs amounted to $4,195/ person, with the greatest expenses for hospitalization and antibiotics. The in-hospital mortality and total medical costs were higher in combined antibiotics therapy than monotherapy (p < 0.05). Charlson's comorbidity index ≥ 3, standardized early warning scoring ≥ 4, sub-fascia infections and combined initial therapy, were all found to be associated with higher mortality. Conclusion: Korean patients with community-onset cSSSI suffer from considerable clinical and economic burden. Efforts should be made to reduce this burden through appropriate initial treatment.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Association of Internal Medicine-
dc.relation.isPartOfKOREAN JOURNAL OF INTERNAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleThe clinical and economic burden of community-onset complicated skin and skin structure infections in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYong Kyun Cho-
dc.contributor.googleauthorHeung Jeong Woo-
dc.contributor.googleauthorShin Woo Kim-
dc.contributor.googleauthorIn-Gyu Bae-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorHee Jin Cheong-
dc.contributor.googleauthorHyuck Lee-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorHee Jung Choi-
dc.contributor.googleauthorChisook Moon-
dc.contributor.googleauthorSeong Yeol Ryu-
dc.contributor.googleauthorJian Hur-
dc.contributor.googleauthorJa Cob Lee-
dc.contributor.googleauthorYu Mi Jo-
dc.contributor.googleauthorYoung Joo Kim-
dc.identifier.doi10.3904/kjim.2018.374-
dc.contributor.localIdA02037-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ02883-
dc.identifier.eissn2005-6648-
dc.identifier.pmid32066225-
dc.subject.keywordClinical burden-
dc.subject.keywordComplicated skin and skin structure infection-
dc.subject.keywordEconomic-
dc.subject.keywordInitial antibiotics-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.affiliatedAuthor송영구-
dc.contributor.affiliatedAuthor한상훈-
dc.citation.volume35-
dc.citation.number6-
dc.citation.startPage1497-
dc.citation.endPage1506-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF INTERNAL MEDICINE, Vol.35(6) : 1497-1506, 2020-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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