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mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김락균 | - |
dc.date.accessioned | 2021-05-21T17:11:11Z | - |
dc.date.available | 2021-05-21T17:11:11Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182756 | - |
dc.description.abstract | T cells maintain a quiescent state prior to activation. As inappropriate T cell activation can cause disease, T cell quiescence must be preserved. Despite its importance, the mechanisms underlying the "quiescent state" remain elusive. Here, we identify BTG1 and BTG2 (BTG1/2) as factors responsible for T cell quiescence. BTG1/2-deficient T cells show an increased proliferation and spontaneous activation due to a global increase in messenger RNA (mRNA) abundance, which reduces the threshold to activation. BTG1/2 deficiency leads to an increase in polyadenylate tail length, resulting in a greater mRNA half-life. Thus, BTG1/2 promote the deadenylation and degradation of mRNA to secure T cell quiescence. Our study reveals a key mechanism underlying T cell quiescence and suggests that low mRNA abundance is a crucial feature for maintaining quiescence. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.relation.isPartOf | SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Immediate-Early Proteins / genetics | - |
dc.subject.MESH | Immediate-Early Proteins / physiology* | - |
dc.subject.MESH | Lymphocyte Activation* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Neoplasm Proteins / genetics | - |
dc.subject.MESH | Neoplasm Proteins / physiology* | - |
dc.subject.MESH | Polyadenylation | - |
dc.subject.MESH | RNA Stability* | - |
dc.subject.MESH | RNA, Messenger / chemistry* | - |
dc.subject.MESH | T-Lymphocytes / immunology* | - |
dc.subject.MESH | Tumor Suppressor Proteins / genetics | - |
dc.subject.MESH | Tumor Suppressor Proteins / physiology* | - |
dc.title | mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Soo Seok Hwang | - |
dc.contributor.googleauthor | Jaechul Lim | - |
dc.contributor.googleauthor | Zhibin Yu | - |
dc.contributor.googleauthor | Philip Kong | - |
dc.contributor.googleauthor | Esen Sefik | - |
dc.contributor.googleauthor | Hao Xu | - |
dc.contributor.googleauthor | Christian C D Harman | - |
dc.contributor.googleauthor | Lark Kyun Kim | - |
dc.contributor.googleauthor | Gap Ryol Lee | - |
dc.contributor.googleauthor | Hua-Bing Li | - |
dc.contributor.googleauthor | Richard A Flavell | - |
dc.identifier.doi | 10.1126/science.aax0194 | - |
dc.contributor.localId | A04520 | - |
dc.relation.journalcode | J02642 | - |
dc.identifier.eissn | 1095-9203 | - |
dc.identifier.pmid | 32165587 | - |
dc.identifier.url | https://science.sciencemag.org/content/367/6483/1255.long | - |
dc.contributor.alternativeName | Kim, Lark Kyun | - |
dc.contributor.affiliatedAuthor | 김락균 | - |
dc.citation.volume | 367 | - |
dc.citation.number | 6483 | - |
dc.citation.startPage | 1255 | - |
dc.citation.endPage | 1260 | - |
dc.identifier.bibliographicCitation | SCIENCE, Vol.367(6483) : 1255-1260, 2020-03 | - |
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