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Impact of diabetes mellitus on mortality in patients with acute heart failure: a prospective cohort study

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dc.contributor.author강석민-
dc.date.accessioned2021-05-21T17:10:41Z-
dc.date.available2021-05-21T17:10:41Z-
dc.date.issued2020-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182748-
dc.description.abstractBackground: Although more than one-third of the patients with acute heart failure (AHF) have diabetes mellitus (DM), it is unclear if DM has an adverse impact on clinical outcomes. This study compared the outcomes in patients hospitalized for AHF stratified by DM and left ventricular ejection fraction (LVEF). Methods: The Korean Acute Heart Failure registry prospectively enrolled and followed 5625 patients from March 2011 to February 2019. The primary endpoints were in-hospital and overall all-cause mortality. We evaluated the impact of DM on these endpoints according to HF subtypes and glycemic control. Results: During a median follow-up of 3.5 years, there were 235 (4.4%) in-hospital mortalities and 2500 (46.3%) overall mortalities. DM was significantly associated with increased overall mortality after adjusting for potential confounders (adjusted hazard ratio [HR] 1.11, 95% confidence interval [CI] 1.03-1.22). In the subgroup analysis, DM was associated with higher a risk of overall mortality in heart failure with reduced ejection fraction (HFrEF) only (adjusted HR 1.14, 95% CI 1.02-1.27). Inadequate glycemic control (HbA1c ≥ 7.0% within 1 year after discharge) was significantly associated with a higher risk of overall mortality compared with adequate glycemic control (HbA1c < 7.0%) (44.0% vs. 36.8%, log-rank p = 0.016). Conclusions: DM is associated with a higher risk of overall mortality in AHF, especially HFrEF. Well-controlled diabetes (HbA1c < 7.0%) is associated with a lower risk of overall mortality compared to uncontrolled diabetes. Trial registration ClinicalTrial.gov, NCT01389843. Registered July 6, 2011. https://clinicaltrials.gov/ct2/show/NCT01389843.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfCARDIOVASCULAR DIABETOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAcute Disease-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiomarkers / blood-
dc.subject.MESHBlood Glucose / drug effects-
dc.subject.MESHBlood Glucose / metabolism-
dc.subject.MESHDiabetes Mellitus / blood-
dc.subject.MESHDiabetes Mellitus / diagnosis-
dc.subject.MESHDiabetes Mellitus / drug therapy-
dc.subject.MESHDiabetes Mellitus / mortality*-
dc.subject.MESHFemale-
dc.subject.MESHGlycated Hemoglobin A / metabolism-
dc.subject.MESHHeart Failure / diagnosis-
dc.subject.MESHHeart Failure / mortality*-
dc.subject.MESHHeart Failure / physiopathology-
dc.subject.MESHHeart Failure / therapy-
dc.subject.MESHHospital Mortality-
dc.subject.MESHHumans-
dc.subject.MESHHypoglycemic Agents / therapeutic use-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHRegistries-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHStroke Volume-
dc.subject.MESHTime Factors-
dc.subject.MESHVentricular Function, Left-
dc.titleImpact of diabetes mellitus on mortality in patients with acute heart failure: a prospective cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorMin Gyu Kong-
dc.contributor.googleauthorSe Yong Jang-
dc.contributor.googleauthorJieun Jang-
dc.contributor.googleauthorHyun-Jai Cho-
dc.contributor.googleauthorSangjun Lee-
dc.contributor.googleauthorSang Eun Lee-
dc.contributor.googleauthorKye Hun Kim-
dc.contributor.googleauthorByung-Su Yoo-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorSang Hong Baek-
dc.contributor.googleauthorDong-Ju Choi-
dc.contributor.googleauthorEun-Seok Jeon-
dc.contributor.googleauthorJae-Joong Kim-
dc.contributor.googleauthorMyeong-Chan Cho-
dc.contributor.googleauthorShung Chull Chae-
dc.contributor.googleauthorByung-Hee Oh-
dc.contributor.googleauthorSoo Lim-
dc.contributor.googleauthorSue K Park-
dc.contributor.googleauthorHae-Young Lee-
dc.identifier.doi10.1186/s12933-020-01026-3-
dc.contributor.localIdA00037-
dc.relation.journalcodeJ00460-
dc.identifier.eissn1475-2840-
dc.identifier.pmid32359358-
dc.subject.keywordAcute heart failure-
dc.subject.keywordDiabetes mellitus-
dc.subject.keywordGlycemic control-
dc.subject.keywordLeft ventricular ejection fraction-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthor강석민-
dc.citation.volume19-
dc.citation.number1-
dc.citation.startPage49-
dc.identifier.bibliographicCitationCARDIOVASCULAR DIABETOLOGY, Vol.19(1) : 49, 2020-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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