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J-curve relationship between corrected QT interval and mortality in acute heart failure patients

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dc.contributor.author강석민-
dc.date.accessioned2021-05-21T17:10:27Z-
dc.date.available2021-05-21T17:10:27Z-
dc.date.issued2020-11-
dc.identifier.issn1226-3303-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182746-
dc.description.abstractBackground/aims: This study investigated the prognostic power of corrected QT (QTc) interval in patients with acute heart failure (AHF) according to sex. Methods: We analyzed multicenter Korean Acute Heart Failure registry with patients with AHF admitted from 2011 to 2014. Among them, we analyzed 4,990 patients who were followed up to 5 years. Regarding QTc interval based on 12 lead electrocardiogram, patients were classified into quartiles according to sex. Results: During follow-up with median 43.7 months, 2,243 (44.9%) patients died. The relationship between corrected QT interval and all-cause mortality followed a J-curve relationship. In Kaplan-Meier analysis, both sex had lowest mortality in the second QTc quartile. There were significant prognostic differences between the second and the fourth quartiles in male (log-rank p = 0.002), but not in female (log-rank p = 0.338). After adjusting covariates, the third (hazard ratio [HR], 1.185; 95% confidence interval [CI], 1.001 to 1.404; p = 0.049) and the fourth (HR, 1.404; 95% CI, 1.091 to 1.535; p = 0.003) quartiles demonstrated increased risk of mortality compared to the second quartile in male. In female, however, there was no significant difference across quartiles. QTc interval was associated with 5-year all-cause mortality in J-shape with nadir of 440 to 450 ms in male and 470 to 480 ms in female. Conclusion: QTc interval was an independent predictor of overall death in male, but its significance decreased in female. The relationship between QTc interval and all-cause mortality was J-shaped in both sex.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Association of Internal Medicine-
dc.relation.isPartOfKOREAN JOURNAL OF INTERNAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleJ-curve relationship between corrected QT interval and mortality in acute heart failure patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorChan Soon Park-
dc.contributor.googleauthorHyun-Jai Cho-
dc.contributor.googleauthorEue-Keun Choi-
dc.contributor.googleauthorSang Eun Lee-
dc.contributor.googleauthorMin-Seok Kim-
dc.contributor.googleauthorJae-Joong Kim-
dc.contributor.googleauthorJin-Oh Choi-
dc.contributor.googleauthorEun-Seok Jeon-
dc.contributor.googleauthorKyung-Kuk Hwang-
dc.contributor.googleauthorShung Chull Chae-
dc.contributor.googleauthorSang Hong Baek-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorByungsu Yoo-
dc.contributor.googleauthorDong-Ju Choi-
dc.contributor.googleauthorYoungkeun Ahn-
dc.contributor.googleauthorKye-Hoon Kim-
dc.contributor.googleauthorMyeong-Chan Cho-
dc.contributor.googleauthorByung-Hee Oh-
dc.contributor.googleauthorHae-Young Lee-
dc.identifier.doi10.3904/kjim.2019.030-
dc.contributor.localIdA00037-
dc.relation.journalcodeJ02883-
dc.identifier.eissn2005-6648-
dc.identifier.pmid32380800-
dc.subject.keywordHeart failure-
dc.subject.keywordMortality-
dc.subject.keywordPrognosis-
dc.subject.keywordQTc interval-
dc.subject.keywordSex-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthor강석민-
dc.citation.volume35-
dc.citation.number6-
dc.citation.startPage1371-
dc.citation.endPage1384-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF INTERNAL MEDICINE, Vol.35(6) : 1371-1384, 2020-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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