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J-curve relationship between corrected QT interval and mortality in acute heart failure patients
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.date.accessioned | 2021-05-21T17:10:27Z | - |
dc.date.available | 2021-05-21T17:10:27Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182746 | - |
dc.description.abstract | Background/aims: This study investigated the prognostic power of corrected QT (QTc) interval in patients with acute heart failure (AHF) according to sex. Methods: We analyzed multicenter Korean Acute Heart Failure registry with patients with AHF admitted from 2011 to 2014. Among them, we analyzed 4,990 patients who were followed up to 5 years. Regarding QTc interval based on 12 lead electrocardiogram, patients were classified into quartiles according to sex. Results: During follow-up with median 43.7 months, 2,243 (44.9%) patients died. The relationship between corrected QT interval and all-cause mortality followed a J-curve relationship. In Kaplan-Meier analysis, both sex had lowest mortality in the second QTc quartile. There were significant prognostic differences between the second and the fourth quartiles in male (log-rank p = 0.002), but not in female (log-rank p = 0.338). After adjusting covariates, the third (hazard ratio [HR], 1.185; 95% confidence interval [CI], 1.001 to 1.404; p = 0.049) and the fourth (HR, 1.404; 95% CI, 1.091 to 1.535; p = 0.003) quartiles demonstrated increased risk of mortality compared to the second quartile in male. In female, however, there was no significant difference across quartiles. QTc interval was associated with 5-year all-cause mortality in J-shape with nadir of 440 to 450 ms in male and 470 to 480 ms in female. Conclusion: QTc interval was an independent predictor of overall death in male, but its significance decreased in female. The relationship between QTc interval and all-cause mortality was J-shaped in both sex. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Association of Internal Medicine | - |
dc.relation.isPartOf | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | J-curve relationship between corrected QT interval and mortality in acute heart failure patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Chan Soon Park | - |
dc.contributor.googleauthor | Hyun-Jai Cho | - |
dc.contributor.googleauthor | Eue-Keun Choi | - |
dc.contributor.googleauthor | Sang Eun Lee | - |
dc.contributor.googleauthor | Min-Seok Kim | - |
dc.contributor.googleauthor | Jae-Joong Kim | - |
dc.contributor.googleauthor | Jin-Oh Choi | - |
dc.contributor.googleauthor | Eun-Seok Jeon | - |
dc.contributor.googleauthor | Kyung-Kuk Hwang | - |
dc.contributor.googleauthor | Shung Chull Chae | - |
dc.contributor.googleauthor | Sang Hong Baek | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Byungsu Yoo | - |
dc.contributor.googleauthor | Dong-Ju Choi | - |
dc.contributor.googleauthor | Youngkeun Ahn | - |
dc.contributor.googleauthor | Kye-Hoon Kim | - |
dc.contributor.googleauthor | Myeong-Chan Cho | - |
dc.contributor.googleauthor | Byung-Hee Oh | - |
dc.contributor.googleauthor | Hae-Young Lee | - |
dc.identifier.doi | 10.3904/kjim.2019.030 | - |
dc.contributor.localId | A00037 | - |
dc.relation.journalcode | J02883 | - |
dc.identifier.eissn | 2005-6648 | - |
dc.identifier.pmid | 32380800 | - |
dc.subject.keyword | Heart failure | - |
dc.subject.keyword | Mortality | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | QTc interval | - |
dc.subject.keyword | Sex | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | 강석민 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1371 | - |
dc.citation.endPage | 1384 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, Vol.35(6) : 1371-1384, 2020-11 | - |
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