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Chimeric Antigen Receptor T Cell Therapy Targeting ICAM-1 in Gastric Cancer
DC Field | Value | Language |
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dc.contributor.author | 노성훈 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 정민규 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 최윤영 | - |
dc.date.accessioned | 2021-05-21T17:08:39Z | - |
dc.date.available | 2021-05-21T17:08:39Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182730 | - |
dc.description.abstract | Cancer therapy utilizing adoptive transfer of chimeric antigen receptor (CAR) T cells has demonstrated remarkable clinical outcomes in hematologic malignancies. However, CAR T cell application to solid tumors has had limited success, partly due to the lack of tumor-specific antigens and an immune-suppressive tumor microenvironment. From the tumor tissues of gastric cancer patients, we found that intercellular adhesion molecule 1 (ICAM-1) expression is significantly associated with advanced stage and shorter survival. In this study, we report a proof-of-concept study using ICAM-1-targeting CAR T cells against gastric cancer. The efficacy of ICAM-1 CAR T cells showed a significant correlation with the level of ICAM-1 expression in target cells in vitro. In animal models of human gastric cancer, ICAM-1-targeting CAR T cells potently eliminated tumors that developed in the lungs, while their efficacy was more limited against the tumors in the peritoneum. To augment CAR T cell activity against intraperitoneal tumors, combinations with paclitaxel or CAR activation-dependent interleukin (IL)-12 release were explored and found to significantly increase anti-tumor activity and survival benefit. Collectively, ICAM-1-targeting CAR T cells alone or in combination with chemotherapy represent a promising strategy to treat patients with ICAM-1+ advanced gastric cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | MOLECULAR THERAPY-ONCOLYTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Chimeric Antigen Receptor T Cell Therapy Targeting ICAM-1 in Gastric Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Minkyu Jung | - |
dc.contributor.googleauthor | Yanping Yang | - |
dc.contributor.googleauthor | Jaclyn E McCloskey | - |
dc.contributor.googleauthor | Marjan Zaman | - |
dc.contributor.googleauthor | Yogindra Vedvyas | - |
dc.contributor.googleauthor | Xianglan Zhang | - |
dc.contributor.googleauthor | Dessislava Stefanova | - |
dc.contributor.googleauthor | Katherine D Gray | - |
dc.contributor.googleauthor | Irene M Min | - |
dc.contributor.googleauthor | Raza Zarnegar | - |
dc.contributor.googleauthor | Yoon Young Choi | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.contributor.googleauthor | Sung Hoon Noh | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Moonsoo M Jin | - |
dc.identifier.doi | 10.1016/j.omto.2020.08.009 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A03606 | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A04138 | - |
dc.relation.journalcode | J03670 | - |
dc.identifier.eissn | 2372-7705 | - |
dc.identifier.pmid | 32995483 | - |
dc.subject.keyword | Chimeric antigen receptor | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | T cell imaging | - |
dc.subject.keyword | inducible cytokines | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | 노성훈 | - |
dc.contributor.affiliatedAuthor | 라선영 | - |
dc.contributor.affiliatedAuthor | 정민규 | - |
dc.contributor.affiliatedAuthor | 정재호 | - |
dc.contributor.affiliatedAuthor | 정현철 | - |
dc.contributor.affiliatedAuthor | 최윤영 | - |
dc.citation.volume | 18 | - |
dc.citation.startPage | 587 | - |
dc.citation.endPage | 601 | - |
dc.identifier.bibliographicCitation | MOLECULAR THERAPY-ONCOLYTICS, Vol.18 : 587-601, 2020-08 | - |
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