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Size and extranodal extension of metastatic lymph nodes in lung adenocarcinoma
DC Field | Value | Language |
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dc.contributor.author | 문덕환 | - |
dc.date.accessioned | 2021-05-21T17:05:40Z | - |
dc.date.available | 2021-05-21T17:05:40Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 2072-1439 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182697 | - |
dc.description.abstract | Background: This study assessed the prognostic significance of metastatic lymph node size (MLNS) and extranodal extension (EN) in patients with node-positive lung adenocarcinoma (ADC). Methods: Prognostic factors influencing survival were analyzed, including age, sex, extent of operation, T- and N-stage, size of tumor, postoperative chemotherapy, presence of EN, and MLNS (>7.0 vs. ≤7.0 mm). Results: Three hundred seventy-five patients met the inclusion criteria were enrolled (mean age: 59.8±10.5 years). Increasing MLNS was significantly correlated with large tumor size (P=0.015), advanced N status (P<0.001), and presence of EN (P<0.001). In multivariable analysis, large tumor size [hazard ratio (HR) 1.135, 95% confidence interval (CI): 1.050 to 1.228, P<0.001], adjuvant chemotherapy (HR 0.582, 95% CI: 0.430 to 0.787, P<0.001), EN (HR 1.454, 95% CI: 1.029 to 2.055, P=0.034), and MLNS greater than 7 mm (HR 1.741, 95% CI: 1.238 to 2.447, P<0.001) were significant prognostic factors for survival. Patients were classified into 3 groups: Group A, MLNS ≤7.0 mm/EN (-); Group B, MLNS ≤7.0 mm/EN (+) or MLNS >7.0 mm/EN (-); and Group C, MLNS >7.0 mm/EN (+). The 5-year overall survival (OS) was 72.2%, 59.0%, and 38.5% in Groups A, B and C, respectively (P<0.001). Conclusions: The MLNS and presence of EN could provide an important prognostic implication for patients with node-positive lung ADC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Pioneer Bioscience Pub. Co. | - |
dc.relation.isPartOf | JOURNAL OF THORACIC DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Size and extranodal extension of metastatic lymph nodes in lung adenocarcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) | - |
dc.contributor.googleauthor | Duk Hwan Moon | - |
dc.contributor.googleauthor | Jin-Ho Choi | - |
dc.contributor.googleauthor | Hee Chul Yang | - |
dc.contributor.googleauthor | Moon Soo Kim | - |
dc.contributor.googleauthor | Jong Mog Lee | - |
dc.contributor.googleauthor | Geon-Kook Lee | - |
dc.contributor.googleauthor | Jae Hyun Jeon | - |
dc.identifier.doi | 10.21037/jtd-20-2039 | - |
dc.contributor.localId | A05708 | - |
dc.relation.journalcode | J01907 | - |
dc.identifier.eissn | 2077-6624 | - |
dc.identifier.pmid | 33282353 | - |
dc.subject.keyword | Lung adenocarcinoma | - |
dc.subject.keyword | follow-up | - |
dc.subject.keyword | lymph node metastasis | - |
dc.subject.keyword | surgery | - |
dc.contributor.alternativeName | Moon, Duk Hwan | - |
dc.contributor.affiliatedAuthor | 문덕환 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 6514 | - |
dc.citation.endPage | 6522 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THORACIC DISEASE, Vol.12(11) : 6514-6522, 2020-11 | - |
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