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Size and extranodal extension of metastatic lymph nodes in lung adenocarcinoma

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dc.contributor.author문덕환-
dc.date.accessioned2021-05-21T17:05:40Z-
dc.date.available2021-05-21T17:05:40Z-
dc.date.issued2020-11-
dc.identifier.issn2072-1439-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182697-
dc.description.abstractBackground: This study assessed the prognostic significance of metastatic lymph node size (MLNS) and extranodal extension (EN) in patients with node-positive lung adenocarcinoma (ADC). Methods: Prognostic factors influencing survival were analyzed, including age, sex, extent of operation, T- and N-stage, size of tumor, postoperative chemotherapy, presence of EN, and MLNS (>7.0 vs. ≤7.0 mm). Results: Three hundred seventy-five patients met the inclusion criteria were enrolled (mean age: 59.8±10.5 years). Increasing MLNS was significantly correlated with large tumor size (P=0.015), advanced N status (P<0.001), and presence of EN (P<0.001). In multivariable analysis, large tumor size [hazard ratio (HR) 1.135, 95% confidence interval (CI): 1.050 to 1.228, P<0.001], adjuvant chemotherapy (HR 0.582, 95% CI: 0.430 to 0.787, P<0.001), EN (HR 1.454, 95% CI: 1.029 to 2.055, P=0.034), and MLNS greater than 7 mm (HR 1.741, 95% CI: 1.238 to 2.447, P<0.001) were significant prognostic factors for survival. Patients were classified into 3 groups: Group A, MLNS ≤7.0 mm/EN (-); Group B, MLNS ≤7.0 mm/EN (+) or MLNS >7.0 mm/EN (-); and Group C, MLNS >7.0 mm/EN (+). The 5-year overall survival (OS) was 72.2%, 59.0%, and 38.5% in Groups A, B and C, respectively (P<0.001). Conclusions: The MLNS and presence of EN could provide an important prognostic implication for patients with node-positive lung ADC.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPioneer Bioscience Pub. Co.-
dc.relation.isPartOfJOURNAL OF THORACIC DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSize and extranodal extension of metastatic lymph nodes in lung adenocarcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)-
dc.contributor.googleauthorDuk Hwan Moon-
dc.contributor.googleauthorJin-Ho Choi-
dc.contributor.googleauthorHee Chul Yang-
dc.contributor.googleauthorMoon Soo Kim-
dc.contributor.googleauthorJong Mog Lee-
dc.contributor.googleauthorGeon-Kook Lee-
dc.contributor.googleauthorJae Hyun Jeon-
dc.identifier.doi10.21037/jtd-20-2039-
dc.contributor.localIdA05708-
dc.relation.journalcodeJ01907-
dc.identifier.eissn2077-6624-
dc.identifier.pmid33282353-
dc.subject.keywordLung adenocarcinoma-
dc.subject.keywordfollow-up-
dc.subject.keywordlymph node metastasis-
dc.subject.keywordsurgery-
dc.contributor.alternativeNameMoon, Duk Hwan-
dc.contributor.affiliatedAuthor문덕환-
dc.citation.volume12-
dc.citation.number11-
dc.citation.startPage6514-
dc.citation.endPage6522-
dc.identifier.bibliographicCitationJOURNAL OF THORACIC DISEASE, Vol.12(11) : 6514-6522, 2020-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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