Cited 0 times in
The Impact of Amyloid-β or Tau on Cognitive Change in the Presence of Severe Cerebrovascular Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류철형 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 조한나 | - |
dc.contributor.author | 최재용 | - |
dc.date.accessioned | 2021-05-21T17:03:41Z | - |
dc.date.available | 2021-05-21T17:03:41Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182679 | - |
dc.description.abstract | Background: As Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) commonly coexist, the interaction between two has been of the considerable interest. Objective: We determined whether the association of Aβ and tau with cognitive decline differs by the presence of significant CSVD. Methods: We included 60 subcortical vascular cognitive impairment (SVCI) from Samsung Medical Center and 82 Alzheimer's disease-related cognitive impairment (ADCI) from ADNI, who underwent Aβ (florbetaben or florbetapir) and tau (flortaucipir, FTP) PET imaging. They were retrospectively assessed for 5.0±3.9 and 5.6±1.9 years with Clinical Dementia Rating-sum of boxes (CDR-SB)/Mini-Mental State Examination (MMSE). Mixed effects models were used to investigate the interaction between Aβ/tau and group on CDR-SB/MMSE changes. Results: The frequency of Aβ positivity (45% versus 54.9%, p = 0.556) and mean global FTP SUVR (1.17±0.21 versus 1.16±0.17, p = 0.702) were not different between the two groups. We found a significant interaction effect of Aβ positivity and SVCI group on CDR-SB increase/MMSE decrease (p = 0.013/p < 0.001), and a significant interaction effect of global FTP uptake and SVCI group on CDR-SB increase/MMSE decrease (p < 0.001 and p = 0.030). Finally, the interaction effects of regional tau and group were prominent in the Braak III/IV (p = 0.001) and V/VI (p = 0.003) not in Braak I/II region (p = 0.398). Conclusion: The association between Aβ/tau and cognitive decline is stronger in SVCI than in ADCI. Therefore, our findings suggested that Aβ positivity or tau burden (particularly in the Braak III/IV or V/VI regions) and CSVD might synergistically affect cognitive decline. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | IOS Press | - |
dc.relation.isPartOf | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The Impact of Amyloid-β or Tau on Cognitive Change in the Presence of Severe Cerebrovascular Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Hyemin Jang | - |
dc.contributor.googleauthor | Hee Jin Kim | - |
dc.contributor.googleauthor | Yeong Sim Choe | - |
dc.contributor.googleauthor | Soo-Jong Kim | - |
dc.contributor.googleauthor | Seongbeom Park | - |
dc.contributor.googleauthor | Yeshin Kim | - |
dc.contributor.googleauthor | Ko Woon Kim | - |
dc.contributor.googleauthor | Chul Hyoung Lyoo | - |
dc.contributor.googleauthor | Hanna Cho | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.contributor.googleauthor | Jae Yong Choi | - |
dc.contributor.googleauthor | Charles DeCarli | - |
dc.contributor.googleauthor | Duk L Na | - |
dc.contributor.googleauthor | Sang Won Seo | - |
dc.identifier.doi | 10.3233/JAD-200680 | - |
dc.contributor.localId | A01333 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A03920 | - |
dc.contributor.localId | A04695 | - |
dc.relation.journalcode | J01231 | - |
dc.identifier.eissn | 1875-8908 | - |
dc.identifier.pmid | 33016911 | - |
dc.identifier.url | https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200680 | - |
dc.subject.keyword | Alzheimer’s disease | - |
dc.subject.keyword | amyloid | - |
dc.subject.keyword | cerebral small vessel diseases | - |
dc.subject.keyword | cognitive dysfunction | - |
dc.subject.keyword | positron emission tomography | - |
dc.subject.keyword | tau | - |
dc.subject.keyword | vascular dementia | - |
dc.contributor.alternativeName | Lyoo, Chul Hyoung | - |
dc.contributor.affiliatedAuthor | 류철형 | - |
dc.contributor.affiliatedAuthor | 유영훈 | - |
dc.contributor.affiliatedAuthor | 조한나 | - |
dc.contributor.affiliatedAuthor | 최재용 | - |
dc.citation.volume | 78 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 573 | - |
dc.citation.endPage | 585 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALZHEIMERS DISEASE, Vol.78(2) : 573-585, 2020-11 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.