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Current Status and Application of Metformin for Prostate Cancer: A Comprehensive Review
DC Field | Value | Language |
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dc.contributor.author | 구교철 | - |
dc.contributor.author | 안현규 | - |
dc.date.accessioned | 2021-05-21T17:02:23Z | - |
dc.date.available | 2021-05-21T17:02:23Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182665 | - |
dc.description.abstract | Metformin, an oral biguanide used for first-line treatment of type 2 diabetes mellitus, has attracted attention for its anti-proliferative and anti-cancer effects in several solid tumors, including prostate cancer (PCa). Liver kinase B1 (LKB1) and adenosine monophosphate-activated protein kinase (AMPK) activation, inhibition of the mammalian target of rapamycin (mTOR) activity and protein synthesis, induction of apoptosis and autophagy by p53 and p21, and decreased blood insulin level have been suggested as direct anti-cancer mechanisms of metformin. Research has shown that PCa development and progression are associated with metabolic syndrome and its components. Therefore, reduction in the risk of PCa and improvement in survival in metformin users may be the results of the direct anti-cancer mechanisms of the drug or the secondary effects from improvement of metabolic syndrome. In contrast, some research has suggested that there is no association between metformin use and PCa incidence or survival. In this comprehensive review, we summarize updated evidence on the relationship between metformin use and oncological effects in patients with PCa. We also highlight ongoing clinical trials evaluating metformin as an adjuvant therapy in novel drug combinations in various disease settings. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antineoplastic Agents / therapeutic use | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols / therapeutic use | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | Autophagy | - |
dc.subject.MESH | Blood Glucose / metabolism | - |
dc.subject.MESH | Clinical Trials as Topic | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p21 / metabolism | - |
dc.subject.MESH | Diabetes Complications / drug therapy | - |
dc.subject.MESH | Diabetes Mellitus, Type 2 / drug therapy* | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Homeostasis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin / metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolic Syndrome / complications | - |
dc.subject.MESH | Metabolic Syndrome / drug therapy* | - |
dc.subject.MESH | Metformin / therapeutic use* | - |
dc.subject.MESH | Prostatic Neoplasms / complications | - |
dc.subject.MESH | Prostatic Neoplasms / drug therapy* | - |
dc.subject.MESH | Protein Kinases / metabolism | - |
dc.subject.MESH | Protein-Serine-Threonine Kinases / metabolism | - |
dc.subject.MESH | Risk | - |
dc.subject.MESH | TOR Serine-Threonine Kinases / metabolism | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Tumor Suppressor Protein p53 / metabolism | - |
dc.title | Current Status and Application of Metformin for Prostate Cancer: A Comprehensive Review | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Hyun Kyu Ahn | - |
dc.contributor.googleauthor | Young Hwa Lee | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.identifier.doi | 10.3390/ijms21228540 | - |
dc.contributor.localId | A00188 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 33198356 | - |
dc.subject.keyword | metformin | - |
dc.subject.keyword | prostatic neoplasm | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.affiliatedAuthor | 구교철 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 8540 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(22) : 8540, 2020-11 | - |
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