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Vaginal compared with intramuscular progestogen for preventing preterm birth in high-risk pregnant women (VICTORIA study): a multicentre, open-label randomised trial and meta-analysis
DC Field | Value | Language |
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dc.contributor.author | 권자영 | - |
dc.date.accessioned | 2021-05-21T16:58:51Z | - |
dc.date.available | 2021-05-21T16:58:51Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 1470-0328 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182641 | - |
dc.description.abstract | Objective: To compare the efficacy of two types of progestogen therapy for preventing preterm birth (PTB) and to review the relevant literature. Design: A multicentre, randomised, open-label, equivalence trial and a meta-analysis. Setting: Tertiary referral hospitals in South Korea. Population: Pregnant women with a history of spontaneous PTB or short cervical length (<25 mm). Methods: Eligible women were screened and randomised at 16-22 weeks of gestation to receive either 200 mg of vaginal micronised progesterone daily (vaginal group) or an intramuscular injection of 250 mg 17α-hydroxyprogesterone caproate weekly (IM group). Stratified randomisation was carried out according to participating centres and indications for progestogen therapy. This trial was registered at ClinicalTrials.gov (NCT02304237). Main outcome measure: Preterm birth (PTB) before 37 weeks of gestation. Results: A total of 266 women were randomly assigned and a total of 247 women (119 and 128 women in the vaginal and IM groups, respectively) were available for the intention-to-treat analysis. Risks of PTB before 37 weeks of gestation did not significantly differ between the two groups (22.7 versus 25.8%, P = 0.571). The difference in PTB risk between the two groups was 3.1% (95% CI -7.6 to 13.8%), which was within the equivalence margin of 15%. The meta-analysis results showed no significant differences in the risk of PTB between the vaginal and IM progestogen treatments. Conclusion: Compared with vaginal progesterone, treatment with intramuscular progestin might increase the risk of PTB before 37 weeks of gestation by as much as 13.8%, or reduce the risk by as much as 7.6%, in women with a history of spontaneous PTB or with short cervical length. Tweetable abstract: Vaginal and intramuscular progestogen showed equivalent efficacy for preventing preterm birth before 37 weeks of gestation. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Administration, Intravaginal | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Injections, Intramuscular | - |
dc.subject.MESH | Meta-Analysis as Topic | - |
dc.subject.MESH | Pregnancy | - |
dc.subject.MESH | Pregnancy, High-Risk | - |
dc.subject.MESH | Premature Birth / prevention & control* | - |
dc.subject.MESH | Progestins / administration & dosage* | - |
dc.title | Vaginal compared with intramuscular progestogen for preventing preterm birth in high-risk pregnant women (VICTORIA study): a multicentre, open-label randomised trial and meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | S-J Choi | - |
dc.contributor.googleauthor | D W Kwak | - |
dc.contributor.googleauthor | K Kil | - |
dc.contributor.googleauthor | S-C Kim | - |
dc.contributor.googleauthor | J-Y Kwon | - |
dc.contributor.googleauthor | Y H Kim | - |
dc.contributor.googleauthor | S Na | - |
dc.contributor.googleauthor | J-G Bae | - |
dc.contributor.googleauthor | H-H Cha | - |
dc.contributor.googleauthor | J-Y Shim | - |
dc.contributor.googleauthor | K Y Oh | - |
dc.contributor.googleauthor | K A Lee | - |
dc.contributor.googleauthor | S M Kim | - |
dc.contributor.googleauthor | I A Cho | - |
dc.contributor.googleauthor | S M Lee | - |
dc.contributor.googleauthor | G J Cho | - |
dc.contributor.googleauthor | Y S Jo | - |
dc.contributor.googleauthor | G Y Choi | - |
dc.contributor.googleauthor | S K Choi | - |
dc.contributor.googleauthor | S E Hur | - |
dc.contributor.googleauthor | H S Hwang | - |
dc.contributor.googleauthor | Y J Kim | - |
dc.identifier.doi | 10.1111/1471-0528.16365 | - |
dc.contributor.localId | A00246 | - |
dc.relation.journalcode | J00339 | - |
dc.identifier.eissn | 1471-0528 | - |
dc.identifier.pmid | 32536019 | - |
dc.identifier.url | https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.16365 | - |
dc.subject.keyword | Preterm birth | - |
dc.subject.keyword | prevention | - |
dc.subject.keyword | progestogen | - |
dc.subject.keyword | short cervical length | - |
dc.contributor.alternativeName | Kwon, Ja Young | - |
dc.contributor.affiliatedAuthor | 권자영 | - |
dc.citation.volume | 127 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 1646 | - |
dc.citation.endPage | 1654 | - |
dc.identifier.bibliographicCitation | BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol.127(13) : 1646-1654, 2020-12 | - |
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