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Intravenous busulfan and melphalan versus high-dose melphalan as a conditioning regimen for early autologous stem cell transplantation in patients with multiple myeloma: a propensity score-matched analysis
DC Field | Value | Language |
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dc.contributor.author | 김진석 | - |
dc.date.accessioned | 2021-05-21T16:49:55Z | - |
dc.date.available | 2021-05-21T16:49:55Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1042-8194 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182582 | - |
dc.description.abstract | We compared the efficacy and toxicity of busulfan and melphalan (BUMEL) and those of high-dose melphalan (HDMEL) as conditioning regimens for autologous stem cell transplantation (ASCT) in patients with multiple myeloma (MM) through a propensity score-matched analysis. No significant difference in the complete response and overall response rate after ASCT was observed between BUMEL and HDMEL. After a median follow-up of 37.3 months in the BUMEL group and 50.8 months in the HDMEL group, the median progression-free survival was calculated to be 32.9 months and 25.2 months (p = 0.995). With respect to non-hematologic toxicities, infections were more frequently reported in the BUMEL group (p < 0.001). Three patients who received BUMEL developed veno-occlusive disease (VOD), and all of them recovered without administration of defibrotide. In conclusion, BUMEL is an effective alternative conditioning regimen in terms of efficacy, but attention should be paid to toxicities. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Informa Healthcare | - |
dc.relation.isPartOf | LEUKEMIA & LYMPHOMA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols / adverse effects | - |
dc.subject.MESH | Busulfan / adverse effects | - |
dc.subject.MESH | Hematopoietic Stem Cell Transplantation* / adverse effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Melphalan / adverse effects | - |
dc.subject.MESH | Multiple Myeloma* / drug therapy | - |
dc.subject.MESH | Propensity Score | - |
dc.subject.MESH | Stem Cell Transplantation | - |
dc.subject.MESH | Transplantation Conditioning | - |
dc.subject.MESH | Transplantation, Autologous | - |
dc.title | Intravenous busulfan and melphalan versus high-dose melphalan as a conditioning regimen for early autologous stem cell transplantation in patients with multiple myeloma: a propensity score-matched analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ga-Young Song | - |
dc.contributor.googleauthor | Sung-Hoon Jung | - |
dc.contributor.googleauthor | Je-Jung Lee | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | Chang-Ki Min | - |
dc.contributor.googleauthor | Kihyun Kim | - |
dc.contributor.googleauthor | Yunsuk Choi | - |
dc.contributor.googleauthor | Hyeon-Seok Eom | - |
dc.contributor.googleauthor | Young Don Joo | - |
dc.contributor.googleauthor | Sung-Hyun Kim | - |
dc.contributor.googleauthor | Jae-Yong Kwak | - |
dc.contributor.googleauthor | Hye Jin Kang | - |
dc.contributor.googleauthor | Jae Hoon Lee | - |
dc.contributor.googleauthor | Ho Sup Lee | - |
dc.contributor.googleauthor | Yeung-Chul Mun | - |
dc.contributor.googleauthor | Joon Ho Moon | - |
dc.contributor.googleauthor | Sang Kyun Sohn | - |
dc.contributor.googleauthor | Seong Kyu Park | - |
dc.contributor.googleauthor | Yong Park | - |
dc.contributor.googleauthor | Ho-Jin Shin | - |
dc.contributor.googleauthor | Sung-Soo Yoon | - |
dc.identifier.doi | 10.1080/10428194.2020.1783448 | - |
dc.contributor.localId | A01017 | - |
dc.relation.journalcode | J02165 | - |
dc.identifier.eissn | 1029-2403 | - |
dc.identifier.pmid | 32580672 | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/10428194.2020.1783448 | - |
dc.subject.keyword | Multiple myeloma | - |
dc.subject.keyword | autologous stem cell transplantation | - |
dc.subject.keyword | conditioning regimen | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | 김진석 | - |
dc.citation.volume | 61 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2714 | - |
dc.citation.endPage | 2721 | - |
dc.identifier.bibliographicCitation | LEUKEMIA & LYMPHOMA, Vol.61(11) : 2714-2721, 2020-11 | - |
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